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Found 420 with Last Name = 'wiggall' and Initial = 'k'
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50001247(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Affinity DataKi:  290nMAssay Description:Binding affinity of compound towards H+/K+ ATPase for activation was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013228(6-Methoxy-4-methyl-1-o-tolyl-2,3-dihydro-1H-pyrrol...)
Affinity DataKi:  290nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132G](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  2.90nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128366(US8802864, 132)
Affinity DataIC50:  3nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  3.80nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  4.60nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128362(US8802864, 42)
Affinity DataIC50:  5nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128359(US8802864, 14)
Affinity DataIC50:  6nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM119133((S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cycloprop...)
Affinity DataIC50:  10nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against HCV 1b NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128360(US8802864, 23)
Affinity DataIC50:  13nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against HCV 2a NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181650(1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-dihydro-1-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128363(US8802864, 67)
Affinity DataIC50:  16nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181560(3-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]th...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128358(US8802864, 7)
Affinity DataIC50:  20nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181569(CHEMBL425221 | [3-(1,1-dioxo-1,4-dihydrobenzo[1,2,...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181589(1-(3,3-dimethylbutyl)-3-(1,1-dioxo-1,4-dihydrobenz...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181588(3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181584(4-[3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181583(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM30406(CHEMBL176058 | benzo[1,2,4]thiadiazine-1,1-dioxide...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181634(6-Amino-1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-di...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181570(5-chloro-3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiad...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181567(4-[3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Sus scrofa (Pig))
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50031989(1-[8-Hydroxymethyl-4-(4-hydroxy-2-methyl-phenylami...)
Affinity DataIC50:  36nMpH: 7.0Assay Description:Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181646(1-(3-bromobenzyl)-3-(1,1-dioxo-1,4-dihydrobenzo[1,...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128365(US8802864, 116)
Affinity DataIC50:  40nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181666(3-(1,1-dioxo-1,4-dihydro-1-benzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  41nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181579(6-chloro-3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiad...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181615(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  46nMT: 2°CAssay Description:For WT IDH1 and IDH2, reactions were conducted at room temperature in 384-well Greiner black microtiter plates in a total volume of 10 μL of ass...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181623(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181601(3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181580(1-(3,3-dimethylbutyl)-3-(1,1-dioxo-1,4-dihydrobenz...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181624(1-cyclobutylmethyl-3-(1,1-dioxo-1,2-dihydrobenzo[1...)
Affinity DataIC50:  49nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  49nMAssay Description:Inhibitory activity against HCV 1a NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181596(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  53nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Sus scrofa (Pig))
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032014(1-[8-(1-Hydroxy-ethyl)-4-(4-hydroxy-2-methyl-pheny...)
Affinity DataIC50:  61nMpH: 7.0Assay Description:Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181598(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181593(6-amino-3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadi...)
Affinity DataIC50:  62nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000672(6-Methoxy-4-methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quin...)
Affinity DataIC50:  64nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181631(3-(1,1-Dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  65nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Sus scrofa (Pig))
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032000(1-[6-Hydroxy-4-(4-hydroxy-2-methyl-phenylamino)-qu...)
Affinity DataIC50:  71nMpH: 7.0Assay Description:Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181660(3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  78nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181578(3-(1,1-dioxo-1,4-dihydro-benzo[1,2,4]thiadiazin-3-...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181653(3-(1,1-dioxo-1,4-dihydro-1-benzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  81nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181605(1-benzyl-3-(1,1-dioxo-1,2-dihydro-benzo[1,2,4]thia...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181654(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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