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Found 163 with Last Name = 'wolfe' and Initial = 'a'
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109574(3-Dimethylcarbamoyloxy-2-(2,2-diphenyl-propionylox...)
Affinity DataKi:  3.14E+3nMAssay Description:Inhibitory activity against Butyrylcholinesterase (BChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109575(2,2-Diphenyl-propionic acid 3-dimethylcarbamoyloxy...)
Affinity DataKi:  5.53E+3nMAssay Description:Inhibitory activity against Butyrylcholinesterase (BChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109574(3-Dimethylcarbamoyloxy-2-(2,2-diphenyl-propionylox...)
Affinity DataKi:  5.62E+3nMAssay Description:Inhibitory activity against Acetylcholinesterase (AChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109572(2,2-Diphenyl-propionic acid 3-dimethylcarbamoyloxy...)
Affinity DataKi:  8.51E+3nMAssay Description:Inhibitory activity against Butyrylcholinesterase (BChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50313079(3-Dimethylcarbamoyloxy-1-methyl-pyridinium; bromid...)
Affinity DataKi:  1.97E+4nMAssay Description:Inhibitory activity against Acetylcholinesterase (AChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109572(2,2-Diphenyl-propionic acid 3-dimethylcarbamoyloxy...)
Affinity DataKi:  3.88E+4nMAssay Description:Inhibitory activity against Acetylcholinesterase (AChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109575(2,2-Diphenyl-propionic acid 3-dimethylcarbamoyloxy...)
Affinity DataKi:  4.59E+4nMAssay Description:Inhibitory activity against Acetylcholinesterase (AChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109573(CHEMBL173694 | Dimethyl-carbamic acid 2-hydroxymet...)
Affinity DataKi:  5.21E+4nMAssay Description:Inhibitory activity against Acetylcholinesterase (AChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50313079(3-Dimethylcarbamoyloxy-1-methyl-pyridinium; bromid...)
Affinity DataKi:  1.14E+5nMAssay Description:Inhibitory activity against Butyrylcholinesterase (BChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109573(CHEMBL173694 | Dimethyl-carbamic acid 2-hydroxymet...)
Affinity DataKi:  1.38E+6nMAssay Description:Inhibitory activity against Butyrylcholinesterase (BChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM23400((2Z)-4-(3-benzylphenyl)-2-hydroxy-4-oxobut-2-enoic...)
Affinity DataIC50:  10nMAssay Description:Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468(CHEMBL32865 | [3-Benzyl-5-(1,1-dioxo-1lambda 6 -is...)
Affinity DataIC50:  10nMAssay Description:Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360722(CHEMBL1934294)
Affinity DataIC50:  24nMAssay Description:Inhibition of BACE1 in cell-free systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360723(CHEMBL1934295)
Affinity DataIC50:  29nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360723(CHEMBL1934295)
Affinity DataIC50:  29nMAssay Description:Inhibition of BACE1 in cell-free systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360724(CHEMBL1934296)
Affinity DataIC50:  36nMAssay Description:Inhibition of BACE1 in cell-free systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123469((3-Benzyl-phenyl)-(8-hydroxy-[1,6]naphthyridin-7-y...)
Affinity DataIC50:  40nMAssay Description:Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123471((4-Benzyl-pyridin-2-yl)-(8-hydroxy-quinolin-7-yl)-...)
Affinity DataIC50:  50nMAssay Description:Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360721(CHEMBL1934293)
Affinity DataIC50:  70nMAssay Description:Inhibition of BACE1 in cell-free systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095515(4-[3-(2-Fluoro-benzyl)-phenyl]-2,4-dioxo-butyric a...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50023916(CHEMBL145335)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360724(CHEMBL1934296)
Affinity DataIC50:  100nMAssay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of soluble APPbeta_NF cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50023918(CHEMBL357909)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50023917(CHEMBL147147)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50023915(CHEMBL343646)
Affinity DataIC50: <100nMAssay Description:Inhibitory activity was determined against recombinant HIV-1 Integrase (0.1 uM) in strand transfer enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM23400((2Z)-4-(3-benzylphenyl)-2-hydroxy-4-oxobut-2-enoic...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50023914(CHEMBL148241)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50176132((Z)-4-(5-Benzyl-2-methoxy-phenyl)-2-hydroxy-4-oxo-...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25363(4-(cyclohexylamino)-1-(3-fluorophenyl)-8-{[3-(2-me...)
Affinity DataIC50:  110nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. After the reaction was terminated, the solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095510(4-(3-Benzyl-5-methoxy-phenyl)-2,4-dioxo-butyric ac...)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360720(CHEMBL1934292)
Affinity DataIC50:  150nMAssay Description:Inhibition of BACE1 in cell-free systemMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095516(4-(3-Benzyl-4-methoxy-phenyl)-2,4-dioxo-butyric ac...)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095513(4-(5-Benzyl-thiophen-3-yl)-2,4-dioxo-butyric acid ...)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM23399(4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-...)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50109574(3-Dimethylcarbamoyloxy-2-(2,2-diphenyl-propionylox...)
Affinity DataIC50:  170nMAssay Description:50 percent inhibitory concentration of Butyrylcholinesterase (BChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095511(4-(2-Benzyl-thiophen-3-yl)-2,4-dioxo-butyric acid ...)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095507(4-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-butyric acid...)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095504(4-[3-(3-Fluoro-benzyl)-phenyl]-2,4-dioxo-butyric a...)
Affinity DataIC50:  250nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123470((3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methan...)
Affinity DataIC50:  370nMAssay Description:Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258280(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50:  470nMpH: 6.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095508(4-(1-Benzyl-1H-pyrrol-3-yl)-2,4-dioxo-butyric acid...)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095502(4-(5-Benzyl-thiophen-2-yl)-2,4-dioxo-butyric acid ...)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360723(CHEMBL1934295)
Affinity DataIC50:  570nMAssay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of soluble APPbeta_NF cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123472(7-Benzyl-1,2-dihydroxy-xanthen-9-one | CHEMBL28809...)
Affinity DataIC50:  600nMAssay Description:Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360717(CHEMBL1934289)
Affinity DataIC50:  600nMAssay Description:Inhibition of BACE1 in cell-free systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095500(4-[3-(4-Chloro-benzyl)-phenyl]-2,4-dioxo-butyric a...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123467((3-Benzyl-phenyl)-(3-hydroxy-furo[3,2-b]pyridin-2-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258849(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50:  1.10E+3nMpH: 4.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 4.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360722(CHEMBL1934294)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of soluble APPbeta_NF cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258280(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of BACE1 (unknown origin) by sAPP_NF cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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