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Found 43 with Last Name = 'yamazaki' and Initial = 'r'
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM649470(US11890288, Compound 11)
Affinity DataIC50:  5.70nMAssay Description:The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof (acetylated histone H4) was evalua...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM649469(US11890288, Compound 1)
Affinity DataIC50:  29nMAssay Description:The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof (acetylated histone H4) was evalua...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM588278(US11542273, Example 9)
Affinity DataIC50:  47nMAssay Description:Table 4-1: The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof was evaluated by the ti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM588281(US11542273, Example 157)
Affinity DataIC50:  61nMAssay Description:Table 4-2: The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof (acetylated histone H4)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM588277(US11542273, Example 8)
Affinity DataIC50:  82nMAssay Description:Table 4-1: The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof was evaluated by the ti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM588280(US11542273, Example 142)
Affinity DataIC50:  110nMAssay Description:Table 4-2: The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof (acetylated histone H4)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataIC50:  550nMAssay Description:The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof (acetylated histone H4) was evalua...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataIC50:  550nMAssay Description:Table 4-2: The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof (acetylated histone H4)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230748(CHEMBL298087)
Affinity DataIC50:  2.00E+3nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataIC50:  7.40E+3nMAssay Description:Table 4-1: The inhibitory action of the compound of the present invention on the binding of BRD4 protein and a ligand thereof was evaluated by the ti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230728(CHEMBL297274)
Affinity DataIC50:  2.60E+4nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50: >6.00E+4nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230743(CHEMBL541042)
Affinity DataIC50: >6.20E+4nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230731(CHEMBL1204204)
Affinity DataIC50: >9.90E+4nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230746(CHEMBL554198)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230742(CHEMBL1202600)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230740(CHEMBL1202605)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230738(CHEMBL544018)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230737(CHEMBL1202595)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230735(CHEMBL541545)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230732(CHEMBL541807)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230730(CHEMBL553647)
Affinity DataIC50: >1.00E+5nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230729(CHEMBL1202604)
Affinity DataIC50: >1.00E+5nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230725(CHEMBL538240)
Affinity DataIC50: >1.00E+5nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230756(CHEMBL1202598)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230755(CHEMBL539255)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230754(CHEMBL538490)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230753(CHEMBL553550)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230752(CHEMBL1202603)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230751(CHEMBL556408)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230750(CHEMBL540528)
Affinity DataIC50: >1.00E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230724(CHEMBL1202602)
Affinity DataIC50: >1.32E+5nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230736(CHEMBL1202599)
Affinity DataIC50: >1.33E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230741(CHEMBL556053)
Affinity DataIC50: >1.67E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230733(CHEMBL1202596)
Affinity DataIC50: >1.67E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230747(CHEMBL557621)
Affinity DataIC50: >1.67E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230734(CHEMBL540275)
Affinity DataIC50: >1.67E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230739(CHEMBL1202597)
Affinity DataIC50: >1.67E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230749(CHEMBL539511)
Affinity DataIC50: >1.67E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230745(CHEMBL1202601)
Affinity DataIC50: >1.67E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230726(CHEMBL555319)
Affinity DataIC50: >1.67E+5nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230727(CHEMBL552576)
Affinity DataIC50: >1.67E+5nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230744(CHEMBL543789)
Affinity DataIC50: >1.67E+5nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed