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Found 2007 with Last Name = 'yao' and Initial = 'y'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human recombinant FLT3 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396023(CHEMBL2169919)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant DOT1L (catalytic domain 1 to 472) using [3H]-SAM by scintillation containingMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396980(CHEMBL2171169)
Affinity DataKi:  0.460nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396980(CHEMBL2171169)
Affinity DataKi:  0.720nMAssay Description:Inhibition of human recombinant DOT1L (catalytic domain 1 to 472) using [3H]-SAM by scintillation containingMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396979(CHEMBL2171170)
Affinity DataKi:  0.760nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50443018(CHEMBL3087503)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant DOT1L (catalytic domain 1 to 472) using [3H]-SAM by scintillation containingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50443019(CHEMBL3087502)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant DOT1L (catalytic domain 1 to 472) using [3H]-SAM by scintillation containingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  11nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50426474(CHEMBL1980391)
Affinity DataKi:  11nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396978(CHEMBL2171171)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396977(CHEMBL2171172)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50437839(CHEMBL2407911)
Affinity DataKi:  22nMAssay Description:Competitive inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50437870(CHEMBL2407901)
Affinity DataKi:  25nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50142238(CHEMBL3759201)
Affinity DataKi:  29nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  40nMAssay Description:Inhibition of AXLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50142187(CHEMBL3758634)
Affinity DataKi:  46nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50142237(CHEMBL3759797)
Affinity DataKi:  58nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396988(CHEMBL2170997)
Affinity DataKi:  58nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396992(CHEMBL2170993)
Affinity DataKi:  70nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396983(CHEMBL2171002)
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396991(CHEMBL2170994)
Affinity DataKi:  82nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  85nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50142242(CHEMBL3759102)
Affinity DataKi:  88nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50437869(CHEMBL2407902)
Affinity DataKi:  100nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50434276(CHEMBL2386125)
Affinity DataKi:  120nMAssay Description:Inhibition of human IDH1 R132C mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  130nMAssay Description:Inhibition of cMETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis)
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50181153(3-(N-hydroxyacetamido)propylphosphonic acid | 3-(N...)
Affinity DataKi:  130nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and MgCl2 as cofactor preinc...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396985(CHEMBL2171000)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396987(CHEMBL2170998)
Affinity DataKi:  140nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50029465(CHEMBL3343445)
Affinity DataKi:  140nMAssay Description:Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50029491(CHEMBL3343464)
Affinity DataKi:  140nMAssay Description:Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis)
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50153713(3-(N-hydroxyformamido)propylphosphonic acid | 3-[F...)
Affinity DataKi:  140nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and MgCl2 as cofactor preinc...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382173(CHEMBL2022157)
Affinity DataKi:  145nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cells by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139118(CHEMBL3759351)
Affinity DataKi:  150nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50029463(CHEMBL3343444)
Affinity DataKi:  150nMAssay Description:Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382173(CHEMBL2022157)
Affinity DataKi:  150nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cells by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382170(CHEMBL2022154)
Affinity DataKi:  153nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cells by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382170(CHEMBL2022154)
Affinity DataKi:  153nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cells by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataKi:  160nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50434278(CHEMBL2386126)
Affinity DataKi:  190nMAssay Description:Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50396990(CHEMBL2170995)
Affinity DataKi:  190nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  200nMAssay Description:Inhibition of PDGFR-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  200nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50142240(CHEMBL3759861)
Affinity DataKi:  200nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50142249(CHEMBL3759939)
Affinity DataKi:  220nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139119(CHEMBL3758849)
Affinity DataKi:  220nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine--tRNA ligase(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  220nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50029489(CHEMBL3343463)
Affinity DataKi:  250nMAssay Description:Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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