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Found 23 with Last Name = 'zaman' and Initial = 'ms'
TargetDihydrofolate reductase(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate preincubated for 1 min followed by DHF addition and mea...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli BL21(DE3) assessed as reduction in consumption of NADPH using DHF a...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  90nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235663(3-[5-(2,4-Dichloro-phenyl)-[1,3,4]oxadiazol-2-yl]-...)
Affinity DataIC50:  400nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235662(3-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-chromen-2-one ...)
Affinity DataIC50:  1.18E+3nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235661(3-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-chro...)
Affinity DataIC50:  1.20E+3nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50537326(CHEMBL4544311)
Affinity DataIC50:  6.79E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli BL21(DE3) assessed as reduction in consumption of NADPH using DHF a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235660(3-(5-Phenyl-[1,3,4]oxadiazol-2-yl)-chromen-2-one (...)
Affinity DataIC50:  8.70E+3nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50516935(CHEMBL4526073)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli BL21(DE3) assessed as reduction in consumption of NADPH using DHF a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  3.05E+4nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235661(3-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-chro...)
Affinity DataIC50:  3.50E+4nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235665(3-(5-o-Tolylamino-[1,3,4]oxadiazol-2-yl)-chromen-2...)
Affinity DataIC50:  3.66E+4nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235663(3-[5-(2,4-Dichloro-phenyl)-[1,3,4]oxadiazol-2-yl]-...)
Affinity DataIC50:  4.16E+4nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50537327(CHEMBL4578986)
Affinity DataIC50:  4.31E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli BL21(DE3) assessed as reduction in consumption of NADPH using DHF a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235660(3-(5-Phenyl-[1,3,4]oxadiazol-2-yl)-chromen-2-one (...)
Affinity DataIC50: <1.00E+5nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235666(4-Chloro-N-[5-(2-oxo-2H-chromen-3-yl)-[1,3,4]oxadi...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235662(3-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-chromen-2-one ...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235666(4-Chloro-N-[5-(2-oxo-2H-chromen-3-yl)-[1,3,4]oxadi...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235664(3-[5-(4-Chloro-phenylamino)-[1,3,4]oxadiazol-2-yl]...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235665(3-(5-o-Tolylamino-[1,3,4]oxadiazol-2-yl)-chromen-2...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Jamia Hamdard University

LigandPNGBDBM235664(3-[5-(4-Chloro-phenylamino)-[1,3,4]oxadiazol-2-yl]...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50537326(CHEMBL4544311)
Affinity DataIC50:  1.25E+5nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate preincubated for 1 min followed by DHF addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50537327(CHEMBL4578986)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate preincubated for 1 min followed by DHF addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed