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Found 1674 with Last Name = 'zheng' and Initial = 'g'
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50194640((2R)-1-((2S,4R)-4-hydroxy-1-[3,3,3-tris(4-fluoroph...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human M3 muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50240552(CHEMBL195)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50240552(CHEMBL195)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50240552(CHEMBL195)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50111346((2-Amino-3-methyl-phenyl)-{4-[4-(3-chloro-benzenes...)
Affinity DataKi:  0.890nMAssay Description:Binding affinity to human M2 muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50240552(CHEMBL195)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177063(3-(4-Bromo-phenyl)-9-dimethylamino-3H-pyrido[3',2'...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50426284(CHEMBL326450)
Affinity DataKi:  1nMAssay Description:Binding affinity to human M4 muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]-MLA binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membraneMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50518557(CHEMBL4519301)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177097(9-Dimethylamino-3-p-tolyl-3H-pyrido[3',2':4,5]thie...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50518557(CHEMBL4519301)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50518557(CHEMBL4519301)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]NMS from human M4 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50518557(CHEMBL4519301)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177065(9-Dimethylamino-3-(2,4-dimethyl-phenyl)-3H-pyrido[...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  4nMAssay Description:Inhibition constant against [3H]-nicotine binding to vesicular monoamine transporter-2 of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177076(3-(4-Chloro-phenyl)-9-dimethylamino-3H-pyrido[3',2...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177055(9-Dimethylamino-3-(3-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50368127(Isoptpo Hyoscine | SCOPOLAMINE)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]NMS from human M3 muscarinic receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50368127(Isoptpo Hyoscine | SCOPOLAMINE)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]NMS from human M1 muscarinic receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177057(9-Dimethylamino-3-(4-trifluoromethyl-phenyl)-3H-py...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50518559(CHEMBL4585326)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177078(9-Dimethylamino-3-(4-fluoro-phenyl)-3H-pyrido[3',2...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataKi:  9.10nMAssay Description:Binding affinity to human M1 muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175681(CHEMBL3809963)
Affinity DataKi:  9.30nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50368127(Isoptpo Hyoscine | SCOPOLAMINE)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50518559(CHEMBL4585326)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50518559(CHEMBL4585326)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177081(3-(2,4-Dichloro-phenyl)-9-dimethylamino-3H-pyrido[...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175683(CHEMBL3808467)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50518557(CHEMBL4519301)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175859(CHEMBL3809825)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50329850((R)-3-Amino-4-[(S)-2-((R)-1-{(S)-1-[(R)-1-(1H-indo...)
Affinity DataKi:  18nMAssay Description:Affinity against ET A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50368127(Isoptpo Hyoscine | SCOPOLAMINE)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50518567(CHEMBL4576768)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175779(CHEMBL3810014)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50426256(CHEMBL2312358)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]NMS from human M1 muscarinic receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50518570(CHEMBL4462631)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175682(CHEMBL3810004)
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175677(CHEMBL3809594)
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50496673(CHEMBL3133793)
Affinity DataKi:  23nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striatal synaptic vesiclesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50518559(CHEMBL4585326)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]NMS from human M4 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192902(2-ethyl-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-he...)
Affinity DataKi:  28nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50433783(CHEMBL2381721)
Affinity DataKi:  29nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striatal synaptic vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50433783(CHEMBL2381721)
Affinity DataKi:  29nMAssay Description:Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50426256(CHEMBL2312358)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175675(CHEMBL3808752)
Affinity DataKi:  30nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50518567(CHEMBL4576768)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50496681(CHEMBL3133789)
Affinity DataKi:  30nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striatal synaptic vesiclesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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