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Found 490 with Last Name = 'zimmermann' and Initial = 'j'
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM50247677((3S,8S)-14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-...)
Affinity DataKi:  40nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataKi:  60nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Affinity DataKi:  110nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM50073099((9E,11E)-(4R,6R,8R)-16-chloro-17,19-dihydroxy-4-me...)
Affinity DataKi:  520nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM50096619(1,8,9-Trihydroxy-3-methoxy-benzo[4,5]furo[3,2-c]ch...)
Affinity DataKi:  600nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM9461(5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  2.03E+3nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM23419((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro...)
Affinity DataKi:  3.43E+3nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50469762(CHEMBL432281)
Affinity DataIC50:  7nMAssay Description:Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50175491(4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of the platelet-derived growth factor receptor.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287090(4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of the platelet-derived growth factor receptor.More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287090(4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of tyrosine kinase(PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50175491(4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of tyrosine kinase(PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50469758(CHEMBL27225)
Affinity DataIC50:  18nMAssay Description:Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073763(3-[9-Ethyl-2-(4-hydroxy-cyclohexylamino)-9H-purin-...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073795(4-[9-Ethyl-6-(3-trifluoromethyl-phenylamino)-9H-pu...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50469765(CHEMBL28320)
Affinity DataIC50:  29nMAssay Description:Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073796(4-[6-(3-Chloro-phenylamino)-9-ethyl-9H-purin-2-yla...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073755(4-[6-(3-Chloro-phenylamino)-9-ethyl-9H-purin-2-yla...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Cyclin-dependent kinase 1, CDK1-related human bladder carcinoma (T24) cell protliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073764(CHEMBL171891 | N*2*-(4-Amino-cyclohexyl)-9-ethyl-N...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073767(4-[9-Ethyl-6-(3-fluoro-phenylamino)-9H-purin-2-yla...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  38nMAssay Description:Inhibition of v-Abl tyrosine kinase.More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073794(CHEMBL367691 | N*2*-(4-Amino-cyclohexyl)-N*6*-(3-c...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073759(CHEMBL173459 | N*2*-(4-Amino-cyclohexyl)-N*6*-(3-c...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073766(CHEMBL176559 | {1-[6-(3-Chloro-phenylamino)-9-ethy...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073759(CHEMBL173459 | N*2*-(4-Amino-cyclohexyl)-N*6*-(3-c...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073798(4-[9-Ethyl-6-(4-fluoro-phenylamino)-9H-purin-2-yla...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073777(CHEMBL368351 | [2-((R)-2-Aminomethyl-pyrrolidin-1-...)
Affinity DataIC50:  41nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287091(CHEMBL20252 | Naphthalene-2-carboxylic acid [4-met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of the platelet-derived growth factor receptor.More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287091(CHEMBL20252 | Naphthalene-2-carboxylic acid [4-met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of tyrosine kinase(PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50469764(CHEMBL27214)
Affinity DataIC50:  50nMAssay Description:Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  50nMAssay Description:Inhibition of the platelet-derived growth factor receptor.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073758(CHEMBL173647 | N*2*-(2-Amino-ethyl)-N*6*-(3-chloro...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073762(CHEMBL366734 | {(R)-1-[6-(3-Chloro-phenylamino)-9-...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073771(3-[2-(4-Amino-cyclohexylamino)-9-ethyl-9H-purin-6-...)
Affinity DataIC50:  85nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073787(4-[9-Ethyl-6-(3-methoxy-phenylamino)-9H-purin-2-yl...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073757(CHEMBL173619 | N*2*-(4-Amino-cyclohexyl)-9-ethyl-N...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50469761(CHEMBL283263)
Affinity DataIC50:  100nMAssay Description:Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290422(4-(4-Methyl-piperazin-1-ylmethyl)-N-[3-(4-pyridin-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of v-Abl tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50469763(CHEMBL279444)
Affinity DataIC50:  100nMAssay Description:Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240407(CHEMBL20926 | N-(4-methyl-3-(4-(pyridin-3-yl)pyrim...)
Affinity DataIC50:  100nMAssay Description:Inhibition of the platelet-derived growth factor receptor.More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240407(CHEMBL20926 | N-(4-methyl-3-(4-(pyridin-3-yl)pyrim...)
Affinity DataIC50:  100nMAssay Description:Inhibition of tyrosine kinase(PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073761(CHEMBL368278 | N*2*-((1S,3R)-3-Amino-cyclohexyl)-N...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM50282567(3,4-Dichlorophenyl boronic acid | 3,4-dichloro ben...)
Affinity DataIC50:  138nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073790(CHEMBL173608 | N*2*-(4-Amino-cyclohexyl)-9-ethyl-N...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073784(CHEMBL366642 | N*2*-(4-Amino-cyclohexyl)-9-ethyl-N...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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