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Found 2820 with Last Name = 'zou' and Initial = 'f'
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29525(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Affinity DataKi:  0.0780nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4D receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29525(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50596723(CHEMBL5205903 | US20230348421, Compound 59)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-Ketanserin from human 5-HT2A receptor at 50 nM incubated for 1 hr by microbeta scintillation counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]CFT from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29525(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4A receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29525(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4C receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29525(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]GR-113808 from human 5HT4e receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29525(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to Rluc fused 5HT4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29525(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Affinity DataKi:  0.530nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4B receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM86038(SL65.0155 | SL650155)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50345562(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
Affinity DataKi:  0.670nMAssay Description:Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237347(CHEMBL4093477)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29525(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to YFP fused 5HT4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50092543(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrim...)
Affinity DataKi:  1nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50160632(3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile | 3-...)
Affinity DataKi:  1.04nMAssay Description:Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50420361(CHEMBL2089181)
Affinity DataKi:  1.29nMAssay Description:Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50160632(3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile | 3-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50092547(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrid...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50092551(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(2,3,5,6...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  1.46nMAssay Description:Binding affinity towards serotonin transporter using [3H]citalopram as radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50317854(5-((6-Methylpyridin-2-yl)ethynyl)nicotinonitrile |...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3HMPEP from rat cloned mGluR5 expressed in HEK293T cells by by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50092550(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrid...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50020222((+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]7-OH-DPAT from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Université

Curated by ChEMBL
LigandPNGBDBM50293279(1-Methyl-5-[(1-propylpiperidin-4-yl)methyloxy]-pyr...)
Affinity DataKi:  1.74nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50020222((+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196226(CHEMBL214234 | S-(+)-2beta-ethenyl-3alpha-[bis(4-f...)
Affinity DataKi:  1.81nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50092546(4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(6-ch...)
Affinity DataKi:  2nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50596723(CHEMBL5205903 | US20230348421, Compound 59)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]- Mesulergine from human 5-HT2C receptor at 300 nM incubated for 1 hr by microbeta2 beta-counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29531(ML10302 scaffold, 9{b;w})
Affinity DataKi:  2nM ΔG°:  -49.7kJ/mole EC50:  68nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50020222((+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50092543(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrim...)
Affinity DataKi:  2.47nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4C receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237356(CHEMBL4078379)
Affinity DataKi:  2.5nMAssay Description:Compound was evaluated for its binding affinity against Toxoplasma gondii purine nucleoside phosphorylase of virulent strain RH (value indicates Non ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50164855(CHEMBL3797209)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50420362(CHEMBL2089182)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity at 5HT3 receptorMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50056446((R)-5-Propylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50059486((2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl...)
Affinity DataKi:  2.94nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50092545(4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(3-me...)
Affinity DataKi:  3nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50174419(1-[2-(4-amino-5-chloro-2-methoxyphenylcarbonyloxy)...)
Affinity DataKi:  3nMAssay Description:Binding affinity for 5-HT4 receptor using [3H]-GR-113,808More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM55121(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50258330(2-(4-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50420359(CHEMBL2089179)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50164855(CHEMBL3797209)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]7-OH-DPAT from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196225(CHEMBL217295 | S-(+)-2beta-Hydroxymethyl-3alpha-[b...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50092548(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrid...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to YFP fused 5HT4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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