Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50028944,50063129,50063139,50063150,50063151,50028944,50063129,50063139,50063150,50063151   

Target72 kDa type IV collagenase(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against Matrix metalloprotease-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 2.60nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloprotease-2 MMP2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 2.70nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 9.60nMAssay Description:Inhibitory activity against Matrix metalloprotease-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063151((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloprotease-2 MMP2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063150((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...)
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloprotease-2 MMP2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloprotease-2 MMP2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063150((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...)
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063151((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...)
Affinity DataIC50: 61nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063151((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063150((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063150((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against endothelin converting enzyme (ECE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063151((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063150((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Endothelin-converting enzyme (ECE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063150((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063150((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063151((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063151((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063150((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against endothelin converting enzyme (ECE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063151((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063151((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Endothelin-converting enzyme (ECE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50028944(CHEMBL1738910)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of MMP7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)