Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50209245,50240903,50270528,50271275,50284964,50209245,50240903,50270528,50271275,50284964   

TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 110nMAssay Description:Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50270528(3-bromo-7-nitro-1H-indazole | 3-BROMO-7-NITROINDAZ...)
Affinity DataIC50: 170nMAssay Description:Inhibition of NOS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50270528(3-bromo-7-nitro-1H-indazole | 3-BROMO-7-NITROINDAZ...)
Affinity DataIC50: 290nMAssay Description:Inhibition of NOS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 600nMAssay Description:Inhibition of rat neuronal NOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 700nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 710nMAssay Description:Inhibition of NOS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 800nMAssay Description:In vitro inhibitory concentration against rat cerebellar neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50270528(3-bromo-7-nitro-1H-indazole | 3-BROMO-7-NITROINDAZ...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of rat brain recombinant nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.00E+3nMAssay Description:Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by neuronal NOS from rat cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetNitric oxide synthase, endothelial(Bovine)
Université

Curated by ChEMBL
LigandPNGBDBM50270528(3-bromo-7-nitro-1H-indazole | 3-BROMO-7-NITROINDAZ...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibitory activity against rat neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Université

Curated by ChEMBL
LigandPNGBDBM50270528(3-bromo-7-nitro-1H-indazole | 3-BROMO-7-NITROINDAZ...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.87E+3nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of NOS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Université

Curated by ChEMBL
LigandPNGBDBM50284964(6-NITROINDAZOLE | 6-Nitro-1H-indazole | CHEMBL5427...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compound was tested for inhibition of inducible Nitric oxide synthase in activated murine macrophages.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetNitric oxide synthase, inducible(Mouse)
Université

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.00E+4nMAssay Description:Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetNitric oxide synthase, inducible(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.40E+4nMAssay Description:Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of rat brain recombinant nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of rat recombinant nNOS expressed in Saccharomyces cerevisiae assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50284964(6-NITROINDAZOLE | 6-Nitro-1H-indazole | CHEMBL5427...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of NOS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Université

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 3.60E+4nMAssay Description:Tested to inhibit the conversion of [3H]-L-arginine to [3H]L-citrulline catalyzed by endothelial NOS from human umbilical vein endothelial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetNitric oxide synthase, inducible(Mouse)
Université

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Université

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Université

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Université

Curated by ChEMBL
LigandPNGBDBM50271275(1H-indazol-7-amine, 1 | CHEMBL463676 | 1H-Indazol-...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50271275(1H-indazol-7-amine, 1 | CHEMBL463676 | 1H-Indazol-...)
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of recombinant NOS1 assessed as citrulline formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Université

Curated by ChEMBL
LigandPNGBDBM50240903(1-methyl-7-nitro-1H-indazole | CHEMBL354723)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Université

Curated by ChEMBL
LigandPNGBDBM50271275(1H-indazol-7-amine, 1 | CHEMBL463676 | 1H-Indazol-...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50240903(1-methyl-7-nitro-1H-indazole | CHEMBL354723)
Affinity DataIC50: 7.00E+5nMAssay Description:Inhibition of rat brain recombinant nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Université

Curated by ChEMBL
LigandPNGBDBM50240903(1-methyl-7-nitro-1H-indazole | CHEMBL354723)
Affinity DataIC50: 7.50E+5nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50271275(1H-indazol-7-amine, 1 | CHEMBL463676 | 1H-Indazol-...)
Affinity DataIC50: 8.50E+5nMAssay Description:Inhibition of rat brain recombinant nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM50271275(1H-indazol-7-amine, 1 | CHEMBL463676 | 1H-Indazol-...)
Affinity DataIC50: 5.00E+6nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)