Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

LigandBDBM50540167(CHEMBL4642463)Copy SMILESCopy InChI

Affinity DataIC50:  6.64E+3nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetBeta-secretase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

LigandBDBM50540167(CHEMBL4642463)Copy SMILESCopy InChI

Affinity DataIC50:  7.33E+3nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

LigandBDBM50540167(CHEMBL4642463)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI