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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
40
hits in this display
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
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Affinity Data
Ki: 0.400nM
Assay Description:
Binding affinity to histamine H3 receptor
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.447nM
Assay Description:
Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
Displacement of [3H]N-alpha methyl histamine from human cloned histamine H3 receptor expressed in C6 cells
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cells
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
Binding affinity to rat cortical histamine H3 receptor
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor
More data for this Ligand-Target Pair
Target Info
PDB
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
Displacement of [3H]-N-alpha methyl histamine from human H3 receptor expressed in C6 cells
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.450nM
Assay Description:
Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells
More data for this Ligand-Target Pair
Target Info
PDB
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Copy BDB DOI
Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.23nM
Assay Description:
In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamine
More data for this Ligand-Target Pair
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Target
Hrh3 protein
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.23nM
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.35nM
Assay Description:
In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.35nM
Assay Description:
Displacement of [3H]-N-alpha methyl histamine from rat H3 receptor expressed in C6 cells
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.35nM
Assay Description:
Binding affinity to human histamine H3 receptor
More data for this Ligand-Target Pair
Target Info
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Article
PubMed
Copy BDB DOI
Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.40nM
Assay Description:
Binding affinity to human histamine H3 receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(GUINEA PIG)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.57nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3nM
Assay Description:
Displacement of [3H]-NAMH from rat histamine H3 receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.20nM
Assay Description:
Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.20nM
Assay Description:
Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.22nM
Assay Description:
Displacement of [3H]N-alpha methyl histamine from rat cortical membrane histamine H3 receptor
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.22nM
Assay Description:
Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in rat cortical membranes
More data for this Ligand-Target Pair
Target Info
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Target
Hrh3 protein
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.24nM
More data for this Ligand-Target Pair
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Target
Histamine receptor H3
(Dog)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.89nM
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4nM
Assay Description:
Displacement of [3H]RAMH from human histamine H3 receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.57nM
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.57nM
Assay Description:
Antagonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as inhibition of RAMH-stimulated [35S]GTPgammaS binding
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.10nM
Assay Description:
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.10nM
Assay Description:
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 31nM
Assay Description:
Displacement of [3H]NAMH from rat histamine H3 receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
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Affinity Data
Ki: 400nM
Assay Description:
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells
More data for this Ligand-Target Pair
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MMDB
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.62E+3nM
More data for this Ligand-Target Pair
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Target
Histamine H2 receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
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Affinity Data
Ki: 6.76E+3nM
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KEGG
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
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Affinity Data
IC50: 0.630nM
Assay Description:
Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
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Affinity Data
EC50: 17.4nM
Assay Description:
Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding
More data for this Ligand-Target Pair
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KEGG
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50139391
((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.29nM
Assay Description:
Agonist activity at human histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI