Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 23 hits in this display   

TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  20nMAssay Description:Inhibition of HDAC5 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  20nMAssay Description:Inhibition of HDAC7 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  30nMAssay Description:Inhibition of HDAC9 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  40nMAssay Description:Inhibition of Class 2A HDAC4 in human Jurkat E6.1 cells using Boc-Lys-(TFA)-AMC as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using Boc-Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of Class 1 HDAC in human HEK293 cells using H4K12 as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of HDAC3/NCOR2 (unknown origin) using Boc-Lys(Ac) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-Arg-Gly-Lys(Ac) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) expressed in human HEK-Freestyle cells using Boc-Lys(Ac) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of HDAC2 (unknown origin) using Ac-Arg-Gly-Lys(Ac) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate incubated for 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-(+)-mephenytoin as substrate incubated for 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataKd: >5.00E+3nMAssay Description:Displacement of [3H]4-DAMP from human recombinant M4 receptor incubated for 1 hr by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataKd: >5.00E+3nMAssay Description:Displacement of [3H]4-DAMP from human recombinant M3 receptor incubated for 1 hr by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataKd: >5.00E+3nMAssay Description:Displacement of [3H]AF-DX384 from human recombinant M2 receptor incubated for 1 hr by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataKd: >5.00E+3nMAssay Description:Displacement of [3H]pirenzapine from human recombinant M1 receptor incubated for 1 hr by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataKd:  3.90E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed