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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
367
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Target
Carbonic anhydrase 3
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 1.10nM
Assay Description:
Inhibition of human carbonic anhydrase 3
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 2.10nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydr...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10nM
Assay Description:
Inhibition of human recombinant cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10nM
Assay Description:
Inhibition of human recombinant full length CA7 by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10nM
Assay Description:
Ki value against human carbonic anhydrase VII
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10nM ΔG°: -49.5kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Carbonic anhydrase (CA) inhibition against hCA II and V11 with synthesized compounds 2-8.
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Copy BDB DOI
Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10nM
Assay Description:
Inhibition of human carbonic anhydrase 7
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Copy BDB DOI
Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Birla Institute Of Technology
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10nM
Assay Description:
Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibitory constant against catalytic domain of human carbonic anhydrase XII
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Ki value against human carbonic anhydrase XII (hCA XII)
More data for this Ligand-Target Pair
Target Info
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KEGG
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CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibitory activity against cloned human CA12
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human recombinant CA12 by CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human recombinant CA12 by CO2 hydration stopped flow assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibitory activity against catalytic domain of human carbonic anhydrase XII
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PC sid
PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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KEGG
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Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition constant against human carbonic anhydrase XI
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydr...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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KEGG
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In Depth
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition assay using carbonic anhydrases.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
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In Depth
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human CA 12 catalytic domain
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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KEGG
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In Depth
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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Ligand Info
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KEGG
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Ligand Info
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KEGG
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40nM
Assay Description:
Inhibition of human carbonic anhydrase 12
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
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Target
Carbonic anhydrase
(Sulfurihydrogenibium sp. (strain YO3AOP1))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 8.20nM
Assay Description:
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 9nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II
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Carbonic anhydrase 6
(Homo sapiens (Human))
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 10nM
Assay Description:
Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay
Checked by Author
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Carbonic anhydrase 6
(Homo sapiens (Human))
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 10nM
Assay Description:
Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay
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Carbonic anhydrase 6
(Homo sapiens (Human))
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 10nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 6
(Homo sapiens (Human))
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 10nM
Assay Description:
Inhibition of human recombinant full length CA6 by stopped flow CO2 hydration assay
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Carbonic anhydrase 6
(Homo sapiens (Human))
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 10nM
Assay Description:
Inhibition of full length human recombinant CA VI
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Carbonic anhydrase 6
(Homo sapiens (Human))
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 10nM
Assay Description:
Inhibition of human carbonic anhydrase 6
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM ΔG°: -44.4kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM ΔG°: -44.8kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM ΔG°: -44.8kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Carbonic anhydrase (CA) inhibition against hCA II and V11 with synthesized compounds 2-8.
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM ΔG°: -44.1kJ/mole
pH: 7.4 T: 2°C
Assay Description:
The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition assay using carbonic anhydrases.
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II.
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibitory constant against human Carbonic anhydrase II
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition constant against human carbonic anhydrase II
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human cloned Carbonic anhydrase II by the CO2 hydration method
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cloned CA2 by CO2 hydration assay
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay
Checked by Author
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
pH: 7.5
Assay Description:
Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 14nM
pH: 7.5
Assay Description:
Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
pH: 7.5
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human recombinant carbonic anhydrase II (CA2)
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human cloned carbonic anhydrase II (hCA II)
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Compound was evaluated for inhibition against human carbonic anhydrase II
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of cloned isozyme, human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase II (CA2)
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human recombinant carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against Human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory effect on human Carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory constant against human Carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against cytosolic human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
In vitro inhibitory activity against human carbonic anhydrase II (hCAII)
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II (hCAII)
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Ki value against human carbonic anhydrase II (hCA II)
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Binding affinity towards human cloned carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Binding affinity towards human cloned carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against human Carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant CA2
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Ki value against human carbonic anhydrase II
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibitory activity against cloned human CA2
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant CA2 by CO2 hydration stopped flow assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cloned CA2 by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cloned CA2 by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase 2
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant full length CA2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant CA2 by stopped-flow CO2 assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant CA2 by stopped-flow hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to ...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to ...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of recombinant human full-length carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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KEGG
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Copy BDB DOI
Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydr...
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human CA2 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of full length human CA 2
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 15.4nM
Assay Description:
Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method
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Target
Carbonic anhydrase 13
(Mus musculus (mouse))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 19nM
Assay Description:
Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 13
(Mus musculus (mouse))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19nM
Assay Description:
Ki value against murine carbonic anhydrase XIII
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 13
(Mus musculus (mouse))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19nM
Assay Description:
Inhibition of mouse carbonic anhydrase 13
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 13
(Mus musculus (mouse))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 13
(Homo sapiens (Human))
University Of Florida
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 19nM
Assay Description:
Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 13
(Mus musculus (mouse))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19nM
Assay Description:
Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 13
(Mus musculus (mouse))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19nM
Assay Description:
Inhibition of mouse recombinant full length CA13 by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
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Carbonic anhydrase
(Stylophora pistillata)
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 21.2nM
Assay Description:
Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay
Checked by Author
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Target
Carbonic anhydrase
(Stylophora pistillata)
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 21.2nM
Assay Description:
Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human CA 9 catalytic domain
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Binding affinity towards human cloned carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against cloned human CA9
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of catalytic domain of human recombinant CA IX
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
PDB
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NCI pathway
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KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human CA9 catalytic domain by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human cloned catalytic domain CA9 by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human carbonic anhydrase 9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
Ligand Info
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against human carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against human carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Ligand Info
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Compound was evaluated for inhibition against human carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
Ligand Info
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CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory concentration against catalytic domain of human cloned carbonic anhydrase IX.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory constant against human Carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory constant against catalytic domain of human carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
Ligand Info
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CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM ΔG°: -42.5kJ/mole
pH: 7.4 T: 2°C
Assay Description:
The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition assay using carbonic anhydrases.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydra...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against human carbonic anhydrase IX.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory constant against human Carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PubMed
Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition constant against human carbonic anhydrase IX
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against catalytic domain of human cloned Carbonic anhydrase IX by the CO2 hydration method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of human cloned CA9 catalytic domain by CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Target
Carbonic anhydrase, alpha family
(Thiomicrospira crunogena (strain XCL-2))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
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Copy BDB DOI
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 34nM
Assay Description:
Inhibition of recombinant human carbonic anhydrase 12 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by pheno...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 36nM
Assay Description:
Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 36nM
Assay Description:
Inhibitory activity against CA4 isolated from bovine lung microsomes
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 36nM
Assay Description:
Inhibitory activity against carbonic anhydrase IV from bovine lung microsomes
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 36nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 36nM
Assay Description:
Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 36nM
Assay Description:
Compound was evaluated for inhibition against bovine carbonic anhydrase IV
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 36nM
Assay Description:
Inhibitory activity against carbonic anhydrase isolated from bovine lung microsome (bCA IV)
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 43nM
Assay Description:
Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 43nM
Assay Description:
Inhibition of human recombinant CA14 by CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 43nM
Assay Description:
Inhibition of human carbonic anhydrase 14
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 43nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 43nM
Assay Description:
Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 43nM
Assay Description:
Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 43nM
Assay Description:
Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 43nM
Assay Description:
Inhibition of human recombinant full length CA14 by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measure...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to ...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydr...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of full length human CA 1
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I (hCAI)
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I at 0.09 uM
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant CA1
More data for this Ligand-Target Pair
Target Info
PDB
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Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Ki value against human carbonic anhydrase I (hCA I)
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Ki value against human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory activity against cloned human CA1
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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3D Structure (crystal)
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human cloned CA1 by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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PDB
3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human cloned CA1 by CO2 hydration method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human carbonic anhydrase 1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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PDB
3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant full length CA1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
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3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant CA1 by stopped-flow CO2 assay
More data for this Ligand-Target Pair
Target Info
PDB
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NCI pathway
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KEGG
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3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
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3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
pH: 7.5
Assay Description:
Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5
More data for this Ligand-Target Pair
Target Info
PDB
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3D Structure (crystal)
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
pH: 7.5
Assay Description:
Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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3D Structure (crystal)
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
pH: 7.5
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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PDB
3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory activity against human cloned carbonic anhydrase I (hCA I)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Compound was evaluated for inhibition against human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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3D Structure (crystal)
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibitory constant against human Carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM ΔG°: -41.0kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM ΔG°: -41.3kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM ΔG°: -41.3kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM ΔG°: -41.7kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition assay using carbonic anhydrases.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay
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Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 62nM
Assay Description:
Inhibition of human carbonic anhydrase 5B
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Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 62nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 62nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 62nM
Assay Description:
Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay
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Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 62nM
Assay Description:
Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay
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Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 62nM
Assay Description:
Inhibition of human recombinant full length CA5B by stopped flow CO2 hydration assay
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Carbonic anhydrase
(Cryptococcus neoformans var. grubii (Filobasidiell...)
Universite Degli Studi Di Firenze
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 63nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 5A, mitochondrial
(Mus musculus (mouse))
UniversitÀ Degli Studi Di Firenze
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 63nM ΔG°: -40.4kJ/mole
pH: 7.4 T: 2°C
Assay Description:
The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...
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Carbonic anhydrase 5A, mitochondrial
(Mus musculus (mouse))
UniversitÀ Degli Studi Di Firenze
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 63nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 15 [19-324]
(Mus musculus (mouse))
University of Tampere
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 65nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 65nM
Assay Description:
Inhibition of human carbonic anhydrase 5A
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Target
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 65nM
Assay Description:
Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 65nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 65nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 65nM
Assay Description:
Inhibition of human recombinant full length CA5A by stopped flow CO2 hydration assay
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Target
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 65nM
Assay Description:
Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 100nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I (hCA I)
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Target
Carbonic anhydrase
(Saccharomyces cerevisiae)
Balikesir University
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 119nM
Assay Description:
Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
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Carbonic anhydrase
(Stylophora pistillata)
Centre Scientifique De Monaco
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 132nM
Assay Description:
Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
Checked by Author
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Carbonic anhydrase
(Methanosarcina thermophila)
Pennsylvania State University
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 145nM
Assay Description:
Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung
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Target
Carbonic anhydrase
(Methanosarcina thermophila)
Pennsylvania State University
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 170nM
Assay Description:
Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila
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Target
Delta carbonic anhydrase
(Thalassiosira weissflogii)
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 170nM
Assay Description:
Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
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Carbonic anhydrase
(Helicobacter pylori (strain G27))
Kochi Medical School
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 171nM
Assay Description:
Inhibition of Helicobacter pylori recombinant CA
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Carbonic anhydrase
(Anopheles gambiae)
University Of Tampere And Tampere University Hospital
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 184nM
Assay Description:
Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay
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CARBONIC ANHYDRASE
(Helicobacter pylori J99)
Kochi Medical School
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 225nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 240nM
Assay Description:
Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes
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Carbonic anhydrase 4
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 240nM
Assay Description:
Inhibition of cloned isozyme, human carbonic anhydrase IV
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 240nM
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 240nM
Assay Description:
Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 240nM
Assay Description:
Inhibitory activity against bovine carbonic anhydrase IV
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
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ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 240nM
Assay Description:
Inhibitory effect on bovine Carbonic anhydrase IV
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
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Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 240nM
Assay Description:
In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)
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Carbonic anhydrase 4
(Homo sapiens (Human))
Universit£
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Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 240nM ΔG°: -37.2kJ/mole
pH: 7.4 T: 2°C
Assay Description:
The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 240nM
Assay Description:
Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes
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Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 280nM
Assay Description:
Inhibition constant against human carbonic anhydrase I
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Carbonic anhydrase
(Astrosclera willeyana)
Slovak Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 326nM
Assay Description:
Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration...
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Carbonic anhydrase
(Candida albicans (Yeast))
Universite Degli Studi Di Firenze
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 484nM ΔG°: -35.4kJ/mole
pH: 8.3 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase
(Mycobacterium tuberculosis)
Kochi Medical School
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 562nM ΔG°: -35.1kJ/mole
pH: 8.3 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase
(Mycobacterium tuberculosis)
Universit£
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ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 562nM
Assay Description:
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay
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Carbonic anhydrase 2
(Mycobacterium tuberculosis)
Universit£
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Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 660nM
Assay Description:
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay
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Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human cloned CA1 by CO2 hydration assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of recombinant human full-length carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-...
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human CA1 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 780nM
Assay Description:
Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Binding affinity towards human cloned carbonic anhydrase I
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Binding affinity towards human cloned carbonic anhydrase I
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against human Carbonic anhydrase I
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against human recombinant carbonic anhydrase I (CA1)
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method.
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of cloned isozyme, human carbonic anhydrase I
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase I (CA1)
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against human recombinant carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human recombinant carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against Human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibitory effect on human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against cytosolic human carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM
Assay Description:
In vitro inhibitory activity against human carbonic anhydrase I (hCAI)
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM ΔG°: -34.9kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM ΔG°: -34.9kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 780nM ΔG°: -34.3kJ/mole
pH: 7.4 T: 2°C
Assay Description:
The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM50013792
(CHEBI:6822 | METHAZOLAMIDE | Neptazane)
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Affinity Data
Ki: 780nM
Assay Description:
Inhibition of human cloned cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against human carbonic anhydrase I.
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibitory constant against human Carbonic anhydrase I
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 780nM
Assay Description:
Inhibitory activity against human cloned Carbonic anhydrase I by the CO2 hydration method
More data for this Ligand-Target Pair
Target Info
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Target
Beta-carbonic anhydrase 1
(Mycobacterium tuberculosis)
Kochi Medical School
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 781nM ΔG°: -34.3kJ/mole
pH: 8.3 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
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Target
Beta-carbonic anhydrase 1
(Mycobacterium tuberculosis)
Kochi Medical School
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 781nM
Assay Description:
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay
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Target
Carbonic anhydrase 4
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 6.20E+3nM
Assay Description:
Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 4
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 6.20E+3nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 4
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 6.20E+3nM
Assay Description:
Inhibition of human carbonic anhydrase 4
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 4
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 6.20E+3nM
Assay Description:
Inhibitory activity against human carbonic anhydrase IV (hCAIV)
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 4
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 6.20E+3nM
Assay Description:
Inhibition of human recombinant full length CA4 by stopped flow CO2 hydration assay
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 1.40E+4nM
Assay Description:
Inhibitory activity against human carbonic anhydrase II at 0.01 uM
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 2.70E+4nM
Assay Description:
Inhibitory activity against human carbonic anhydrase IX at 0.09 uM
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Target
Carbonic anhydrase
(Methanobacterium thermoautotrophicum)
Pennsylvania State University
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 3.21E+4nM
Assay Description:
Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum
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Target
Carbonic anhydrase 3
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: >2.00E+5nM ΔG°: >-21.1kJ/mole
pH: 7.4 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 3
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 7.00E+5nM
Assay Description:
Inhibition of human recombinant full length CA3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assay
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Target
Carbonic anhydrase 3
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 7.00E+5nM
Assay Description:
Inhibition of human recombinant cytosolic carbonic anhydrase 3 preincubated for 15 mins by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 3
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Copy SMILES
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Affinity Data
Ki: 7.00E+5nM
Assay Description:
Inhibition of human full length carbonic anhydrase 3 by stopped flow CO2 hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 3
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
Ki: 7.70E+5nM
Assay Description:
Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kinetic assay
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Carbonic anhydrase 9
(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 0.25nM
Assay Description:
Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay
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Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 4.80nM
Assay Description:
Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 12.5nM
Assay Description:
The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 14nM EC50: 40nM
Assay Description:
CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 14nM
Assay Description:
Inhibitory activity of compound against human carbonic anhydrase II
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Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM315269
(US10172837, Methazolamide)
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Affinity Data
IC50: 14nM
Assay Description:
Compounds which are CAIs are well known in the art, see for example, Pastorekova et al, Journal of Enzyme Inhibition and Medicinal Chemistry, 19(3), ...
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Carbonic anhydrase 4
(Bos taurus (bovine))
Universit£
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Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 36nM
Assay Description:
Inhibitory activity of compound against bovine carbonic anhydrase IV
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Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibitory activity of compound against human carbonic anhydrase I
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Enscm/Umii/Umr-Cnrs 5635
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 68nM
Assay Description:
Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay
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Carbonic anhydrase 4
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
IC50: 205nM
Assay Description:
The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...
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Target
Corticotropin-releasing factor-binding protein
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
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Affinity Data
EC50: >5.30E+4nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
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