Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 31 hits in this display
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
Ki: 5.10E+3nM ΔG°: -30.2kJ/mole IC50: 1.08E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
Ki: 6.30E+3nM ΔG°: -29.7kJ/mole IC50: 1.15E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: 64nMAssay Description:Inhibition of human recombinant HDAC3 at 0.5 uM using AMC-K(Ac)GL as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: 1.08E+3nMAssay Description:Inhibition of human recombinant HDAC1 at 0.1 uM using AMC-K(Ac)GL as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: 1.15E+3nMAssay Description:Inhibition of human recombinant HDAC2 at 0.1 uM using AMC-K(Ac)GL as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: 1.25E+3nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: >3.00E+4nMAssay Description:Inhibition of human HDAC5 using carboxyfluorescein (FAM)-labeled acetylated peptide substrate by microfluidic capillary electrophoresisMore data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: >3.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide substrate by microfluidic capillary electrophoresisMore data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
BDBM178100(BRD3308 | US11377423, Cmpd 1)
IC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair