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Target
Histone deacetylase 1
Ligand
BDBM178100
Substrate
n/a
Meas. Tech.
In-vitro HDAC Enzymatic Endpoint Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
5.1e+3±n/a nM
IC50
1.08e+3± 4.4e+2 nM
Comments
extracted
Citation
 Wagner, FF; Lundh, M; Kaya, T; McCarren, P; Zhang, YL; Chattopadhyay, S; Gale, JP; Galbo, T; Fisher, SL; Meier, BC; Vetere, A; Richardson, S; Morgan, NG; Christensen, DP; Gilbert, TJ; Hooker, JM; Leroy, M; Walpita, D; Mandrup-Poulsen, T; Wagner, BK; Holson, EB An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in ß-Cell Protection. ACS Chem Biol 11:363-74 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM178100
Synonyms:
BRD3308 | US11377423, Cmpd 1
Type:
Small organic molecule
Emp. Form.:
C15H14FN3O2
Mol. Mass.:
287.289
SMILES:
CC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(F)cc1N
Structure:
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