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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
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Target
dCTP pyrophosphatase 1
(Homo sapiens (Human))
Yale University
Ligand
BDBM50241049
(CHEMBL463763 | Triptolide, 1 | triptolide)
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Affinity Data
Ki: 1.68E+5nM ΔG°: -21.5kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Kinetic enzyme assays were performed in a 384-well, white plates (Nunc) on a Wallac Victor 2 plate reader using human DCTPP1 and triptolide and analo...
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Target Info
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Target
Proteinase-activated receptor 2
(Homo sapiens (Human))
The University Of Queensland
Curated by
ChEMBL
Ligand
BDBM50241049
(CHEMBL463763 | Triptolide, 1 | triptolide)
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Affinity Data
IC50: 14nM
Assay Description:
Antagonist activity at human PAR2 expressed in human A549 cells assessed as inhibition of 2f-LIGRLO-NH2-induced NFkappaB activation by luciferase rep...
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Target
Proteinase-activated receptor 2
(Homo sapiens (Human))
The University Of Queensland
Curated by
ChEMBL
Ligand
BDBM50241049
(CHEMBL463763 | Triptolide, 1 | triptolide)
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Affinity Data
IC50: 23nM
Assay Description:
Antagonist activity at human PAR2 expressed in human A549 cells coexpressing TACR1 assessed as inhibition of substance P-induced IL-8 production by E...
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50241049
(CHEMBL463763 | Triptolide, 1 | triptolide)
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Affinity Data
IC50: 40nM
Assay Description:
Inhibition of COX2
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Target Info
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antibodypedia
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Target
dCTP pyrophosphatase 1
(Homo sapiens (Human))
Yale University
Ligand
BDBM50241049
(CHEMBL463763 | Triptolide, 1 | triptolide)
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Affinity Data
IC50: 3.09E+4nM
Assay Description:
Inhibition of human dCTPase 1
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
KEGG
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
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Target
dCTP pyrophosphatase 1
(Homo sapiens (Human))
Yale University
Ligand
BDBM50241049
(CHEMBL463763 | Triptolide, 1 | triptolide)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.09E+4nM
Assay Description:
Inhibition of dCTPase 1 (unknown origin) expressed in Escherichia coli BL21 Star (DE3) using dCTP as substrate by luminescence assay
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
dCTP pyrophosphatase 1
(Homo sapiens (Human))
Yale University
Ligand
BDBM50241049
(CHEMBL463763 | Triptolide, 1 | triptolide)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.09E+4nM
Assay Description:
Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
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PC sid
PDB
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
dCTP pyrophosphatase 1
(Homo sapiens (Human))
Yale University
Ligand
BDBM50241049
(CHEMBL463763 | Triptolide, 1 | triptolide)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.09E+4nM
Assay Description:
Inhibition of human recombinant DCTPP1 expressed in Escherichia coli BL21 Star (DE3) using dCTP as substrate by PPiLight assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI