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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 14 hits in this display   

TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  0.760nMAssay Description:The compound was tested for inhibition of IL-1 beta converting enzyme in whole human blood.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  6nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  9nMAssay Description:Inhibition of mouse ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50091566(3-(2-{2-[2-Acetylamino-3-(4-hydroxy-phenyl)-propio...)
Affinity DataIC50:  0.760nMAssay Description:Dissociation constant for inhibition of caspase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  8.10nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  8.40nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of caspase 1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 beta(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Induction of IL-1 beta production in LPS-induced human THP-1 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Ability to inhibit IL-1 beta converting enzyme was evaluated in LPS-stimulated human whole bloodChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  6.80E+4nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  1.90E+5nMAssay Description:Amidolytic activity of THP.1 cell lysate against Caspase-3 using C3-Asp-AMC as a substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50091566(3-(2-{2-[2-Acetylamino-3-(4-hydroxy-phenyl)-propio...)
Affinity DataKoff:  3.80E+5s-1Assay Description:Evaluated for kinetic dissociation constant (kon) for the inhibition of caspase-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed