Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 148 hits in this display
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Ki: 3.50E+3nMAssay Description:Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysisMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM50367209(BESTATIN HYDROCHLORIDE | Ubenimex)
BDBM50367209(BESTATIN HYDROCHLORIDE | Ubenimex)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM50367209(BESTATIN HYDROCHLORIDE | Ubenimex)
Ki: 7.00E+3nMAssay Description:Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1More data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM50367209(BESTATIN HYDROCHLORIDE | Ubenimex)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 1.60nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM50367209(BESTATIN HYDROCHLORIDE | Ubenimex)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 3.50E+3nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 3.70E+3nMAssay Description:Inhibition of pig kidney microsomal APN assessed as hydrolysis of L-Leu-p-nitroanilide after 1 hr by spectrophotometryMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 1.73E+4nMAssay Description:Inhibition of CD13 in human ES-2 cell surface using L-leucine-p-nitroanilide as substrate and measured after 1 hr by microplate reader analysisMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 1.73E+4nMAssay Description:Inhibition of CD13 in human A549 cell surface using L-leucine-p-nitroanilide as substrate and measured after 1 hr by microplate reader analysisMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 1.94E+4nMAssay Description:Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrateMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 2.01E+4nMAssay Description:Inhibition of APN in human ES2 cells preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 1 hr by photometryMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 3.55E+4nMAssay Description:Inhibition of APN in human ES2 cells using L-Leu-pnitroanilide as substrate pretreated for 5 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 4.07E+4nMAssay Description:Inhibition of CD13 in human PLC-PRF-5 cell surface using L-leucine-p-nitroanilide as substrate and measured after 1 hr by microplate reader analysisMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 4.50E+4nMAssay Description:Inhibition of recombinant ERAP1 (unknown origin) expressed in baculovirus infected Hi-5 insect cells using L-AMC as substrate by flourescence assayMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: 5.00E+4nMAssay Description:Inhibition of human ERAP1 expressed in African green monkey COS7 cells using aminoacyl-4-methylcoumaryl-7-amide as substrate after 15 mins by spectro...More data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: >1.00E+5nMAssay Description:Inhibition of recombinant IRAP (unknown origin) expressed in HEK293S cells using L-AMC as substrate by flourescence assayMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: >1.00E+5nMAssay Description:Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus infected Hi-5 insect cells using R-AMC as substrate by flourescence assayMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: >3.24E+5nMAssay Description:Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
IC50: >3.24E+5nMAssay Description:Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Kd: 5.15E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Kd: 4.63E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
BDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Kd: 2.05E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
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