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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
14
hits in this display
Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
Niigata College of Pharmacy
Curated by
PDSP K
i
Database
Ligand
BDBM25752
(Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)
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Affinity Data
Ki: 12.3nM
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Target
Beta-2 adrenergic receptor
(Rattus norvegicus)
Niigata College of Pharmacy
Curated by
PDSP K
i
Database
Ligand
BDBM25752
(Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)
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Affinity Data
Ki: 2.04E+3nM
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Niigata College of Pharmacy
Curated by
PDSP K
i
Database
Ligand
BDBM25752
(Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50405521
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
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Affinity Data
IC50: 37nM
Assay Description:
Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart
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Target
Beta-2 adrenergic receptor
(BOVINE)
TBA
Curated by
ChEMBL
Ligand
BDBM50405521
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
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Affinity Data
IC50: 657nM
Assay Description:
Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50404948
(BETAXOLOL | Betoptic | Betoptic S | CHEMBL1369414 ...)
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Affinity Data
IC50: 6.60E+4nM
Assay Description:
Inhibitory activity against recombinant human Cytochrome P450 2D6 (CYP2D6) after incubated for 45 minutes
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50405521
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target Info
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Target
Beta-1 adrenergic receptor
(GUINEA PIG)
TBA
Curated by
ChEMBL
Ligand
BDBM50405521
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
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Affinity Data
Kd: 1.70nM
Assay Description:
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...
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Target Info
PDB
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ChEBI
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Target
Beta-2 adrenergic receptor
(BOVINE)
TBA
Curated by
ChEMBL
Ligand
BDBM50405521
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
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Affinity Data
Kd: 1.86E+5nM
Assay Description:
Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)
More data for this Ligand-Target Pair
Target Info
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KEGG
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In Depth
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Article
PubMed
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Target
Beta-2 adrenergic receptor
(BOVINE)
TBA
Curated by
ChEMBL
Ligand
BDBM50405521
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
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Affinity Data
Kd: 93nM
Assay Description:
Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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B.MOAD
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In Depth
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Article
PubMed
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
University of Nottingham
Ligand
BDBM25752
(Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)
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Affinity Data
Kd: 1.07E+3nM
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Article
PubMed
Copy BDB DOI
Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM25752
(Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 6.20nM
pH: 7.4 T: 2°C
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
University of Nottingham
Ligand
BDBM25752
(Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 42nM
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-2 adrenergic receptor
(GUINEA PIG)
TBA
Curated by
ChEMBL
Ligand
BDBM50405521
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Copy SMILES
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Affinity Data
Kd: 105nM
Assay Description:
In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tr...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
DrugBank
MCE
KEGG
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI