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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
20
hits in this display
Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
Ki: 530nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Purdue University
Curated by
ChEMBL
Ligand
BDBM50227457
(CHEMBL1788285)
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Affinity Data
Ki: 1.38E+3nM
Assay Description:
Displacement of [3H]5-HT from 5-HT1B receptor of rat frontal cortex homogenate
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Purdue University
Curated by
ChEMBL
Ligand
BDBM50227466
(CHEMBL2093087)
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Affinity Data
Ki: 1.51E+3nM
Assay Description:
Displacement of [3H]5-HT from 5-HT1B receptor of rat frontal cortex homogenate
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
Purdue University
Curated by
ChEMBL
Ligand
BDBM50227457
(CHEMBL1788285)
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Affinity Data
Ki: 4.27E+3nM
Assay Description:
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat frontal cortex homogenate
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
Purdue University
Curated by
ChEMBL
Ligand
BDBM50227466
(CHEMBL2093087)
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Affinity Data
Ki: 5.13E+3nM
Assay Description:
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat frontal cortex homogenate
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Target
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]Epibatidine from human recombinant alpha2beta4 nACh receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counti...
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]LY278584 from human recombinant 5-HT3 receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting an...
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Target
Histamine H2 receptor
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]Tiotidine from human recombinant histamine H2 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting ana...
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]N-methylspiperone from human recombinant dopamine D2 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation count...
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-4
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Copy InChI
Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]Epibatidine from human recombinant alpha4beta4 nACh receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counti...
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]Epibatidine from alpha4beta2 nACh receptor in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]Epibatidine from human recombinant alpha4beta2 nACh receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counti...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
antibodypedia
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PubMed
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
Purdue University
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Copy InChI
Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 2 receptor using [3H]ketanserin as radioligand
More data for this Ligand-Target Pair
Target Info
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Target
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-2
(Homo sapiens (Human))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]Epibatidine from human recombinant alpha2beta2 nACh receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counti...
More data for this Ligand-Target Pair
Target Info
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Target
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig))
Ucl School Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]Pentazocine from guinea pig sigma 1 receptor after 1 to 1.5 hrs by scintillation counting analysis
More data for this Ligand-Target Pair
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Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
EC50: 112nM
Assay Description:
Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assay
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
EC50: 79nM
Assay Description:
Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assay
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
EC50: 22nM
Assay Description:
Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assay
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50014210
(1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl...)
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Affinity Data
EC50: 23nM
Assay Description:
Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay
More data for this Ligand-Target Pair
Target Info
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