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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
17
hits in this display
Target
Cathepsin S
(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
Ki: >10nM
Assay Description:
Inhibition of human recombinant cathepsin S by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Ligand Info
CHEMBL
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Target
Cathepsin B
(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
Ki: >10nM
Assay Description:
Inhibition of human recombinant cathepsin B by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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Article
PubMed
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Target
Pro-cathepsin H
(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
Ki: 3.70E+3nM
Assay Description:
Inhibition of human recombinant cathepsin H by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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Article
PubMed
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Target
Cathepsin K
(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
Ki: 1.80E+4nM
Assay Description:
Inhibition of human recombinant cathepsin K by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
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Target
Dipeptidyl peptidase 1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition of recombinant human cathepsin C using H-Gly-Arg-AMC as substrate preincubated for 30 mins before substrate addition measured after 60 min...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Dipeptidyl peptidase 1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: 13nM
Assay Description:
Inhibition of human DPP1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Dipeptidyl peptidase 1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: 63nM
Assay Description:
Inhibition of cathepsin C in human THP1 cells assessed as inhibition of H-Gly-Phe-AFC cleavage by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Arpida
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: 3.60E+3nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Dipeptidyl peptidase 1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: 6.10E+3nM
Assay Description:
Inhibition of cathepsin C in human B721 cells by FACS assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Pro-cathepsin H
(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of Cathepsin H
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Cathepsin B
(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of Cathepsin B
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Procathepsin L
(Homo sapiens (Human))
Arpida
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of Cathepsin L
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Dipeptidyl peptidase 1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Blockade of conjugation of cathepsin C in human B721 cells to I125-labeled (S)-2-amino-N-((S)-1-(4-hydroxy-3-iodophenylsulfonyl)-5-phenylpent-1-en-3-...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Arpida
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: 1.26E+4nM
Assay Description:
Inhibition of CYP2D6
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Arpida
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
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Affinity Data
IC50: 1.49E+4nM
Assay Description:
Inhibition of CYP1A2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Arpida
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Copy SMILES
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2C19
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Arpida
Curated by
ChEMBL
Ligand
BDBM50186088
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2C9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI