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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
58
hits in this display
Target
Lactoylglutathione lyase
(Mus musculus)
Chengdu University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
Ki: 290nM
Assay Description:
Inhibition of recombinant mouse Glyoxalase-1 expressed in Escherichia coli BL21 (DE3) pLysS cells using GSH and MGO as substrate by Dixon plot
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Target
Solute carrier organic anion transporter family member 1B1
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
Ki: 290nM
Assay Description:
Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells
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Target
Solute carrier organic anion transporter family member 1B3
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
Ki: 420nM
Assay Description:
Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells
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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-321]
(Homo sapiens (Human))
Cold Spring Harbor Laboratory
US Patent
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...
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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-405]
(Homo sapiens (Human))
Cold Spring Harbor Laboratory
US Patent
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...
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Target
Cholinesterase
(Equus caballus (Horse))
Martin-Luther-Universit£T Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 20 mins measured for 1 min interval for 30 mins by Ellman's method
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Target
Acetylcholinesterase
(Electrophorus electricus (Electric eel))
Martin-Luther-Universit£T Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate after 20 mins measured for 1 min interval for 30 mins by Ellm...
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Target
11-beta-hydroxysteroid dehydrogenase type 2
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 1.20nM
Assay Description:
Inhibition of human 11beta-HSD2
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Target
11-beta-hydroxysteroid dehydrogenase type 2
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 1.20nM
Assay Description:
Inhibition of human 11beta-HSD2 overexpressed in microsomal fraction of HEK293 cells using [3H]-cortisol as substrate by scintillation proximity assa...
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Target
11-beta-hydroxysteroid dehydrogenase type 2
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 1.30nM
Assay Description:
Inhibition of full-length human 11beta-HSD2 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox...
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition of mouse 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol by scintillati...
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Target Info
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...
More data for this Ligand-Target Pair
Target Info
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 7.40nM
Assay Description:
Inhibition of full-length mouse 11beta-HSD1 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 1 hr by scintillation prox...
More data for this Ligand-Target Pair
Target Info
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 8.60nM
Assay Description:
Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...
More data for this Ligand-Target Pair
Target Info
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
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Affinity Data
IC50: 8.80nM
Assay Description:
Inhibition of human microsomal 11beta-HSD1 overexpressed in HEK293 cells using [3H]-cortisone as substrate assessed as formation of [3H]-cortisol usi...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9.40nM
Assay Description:
Inhibition of mouse microsomal 11beta-HSD1 overexpressed in HEK293 cells using [3H]-cortisone as substrate assessed as formation of [3H]-cortisol usi...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
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Affinity Data
IC50: 10.6nM
Assay Description:
Inhibition of mouse 11beta-HSD1
More data for this Ligand-Target Pair
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibition of full-length human 11beta-HSD1 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox...
More data for this Ligand-Target Pair
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
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Affinity Data
IC50: 11.8nM
Assay Description:
Inhibition of human 11beta-HSD1
More data for this Ligand-Target Pair
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 13nM
Assay Description:
Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 29nM
Assay Description:
Inhibition of human 11beta-HSD1 overexpressed in microsomal fraction of HEK293 cells assessed as formation of [3H]-cortisol from [3H]-cortisone by sc...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 29nM
Assay Description:
Inhibition of human 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol by scintillati...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
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Affinity Data
IC50: 40nM
Assay Description:
Inhibition of mouse 11beta-HSD1 overexpressed in microsomal fraction of HEK293 cells assessed as formation of [3H]-cortisol from [3H]-cortisone by sc...
More data for this Ligand-Target Pair
Target Info
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Rattus norvegicus (rat))
University Of Technology
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 90nM
Assay Description:
Inhibition of rat hepatic 11beta-HSD1
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Rattus norvegicus (rat))
University Of Technology
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 90nM
Assay Description:
Inhibition of 11beta-HSD1 in rat liver assessed as cortisone level
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Target
11-beta-hydroxysteroid dehydrogenase type 2
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 257nM
Assay Description:
Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...
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Target
11-beta-hydroxysteroid dehydrogenase type 2
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
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Affinity Data
IC50: 257nM
Assay Description:
Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...
More data for this Ligand-Target Pair
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Target
11-beta-hydroxysteroid dehydrogenase type 2
(Rattus norvegicus)
University Of Technology
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 360nM
Assay Description:
Inhibition of rat renal 11beta-HSD2
More data for this Ligand-Target Pair
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Target
11-beta-hydroxysteroid dehydrogenase type 2
(Rattus norvegicus)
University Of Technology
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Copy SMILES
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Affinity Data
IC50: 360nM
Assay Description:
Inhibition of rat renal 11beta-HSD2 in rat liver assessed as inhibition of cortisone production
More data for this Ligand-Target Pair
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Target
Solute carrier organic anion transporter family member 1B1
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 525nM
Assay Description:
pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells
More data for this Ligand-Target Pair
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Target
Solute carrier organic anion transporter family member 1B3
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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IC50: 550nM
Assay Description:
pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells
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11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 778nM
Assay Description:
Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-3H]-cortisone to cortisol by scintillation count...
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 778nM
Assay Description:
Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-[3H]cortisone to cortisol after 10 mins by scint...
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Shanghai Pharmaceutical Holding
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 779nM
Assay Description:
Inhibition of human 11beta-HSD1 expressed in HEK293 cells measured after 10 mins
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Target
Aldo-keto reductase family 1 member B10
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 4.90E+3nM
Assay Description:
Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...
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Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 9.60E+3nM
Assay Description:
Inhibition of recombinant SHP2
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Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 9.60E+3nM
Assay Description:
Inhibition of SHP2 (unknown origin)
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Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of Pin1 (unknown origin) assessed as reduction in peptidyl-prolyl isomerase activity incubated for 30 mins using Suc-Ala-Glu-cis-Pro-Phe-4...
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Beta-glucuronidase
(Escherichia coli (Enterobacteria))
University Of Kwazulu-Natal
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 1.22E+4nM
Assay Description:
Inhibition of Escherichia coli beta-glucuronidase
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Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of TCPTP (unknown origin) by pNPP assay
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Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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IC50: >2.00E+4nM
Assay Description:
Inhibition of PTP1B (unknown origin) by pNPP assay
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Liver carboxylesterase 1
(Homo sapiens (Human))
Dalian Institute Of Chemical Physics
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 2.10E+4nM
Assay Description:
Inhibition of CE1 in human liver microsomes using 2-(2-Benzoyl-3-methoxyphenyl) benzothiazole as substrate preincubated for 10 mins followed by subst...
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Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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IC50: 2.48E+4nM
Assay Description:
Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 2.48E+4nM
Assay Description:
Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...
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Polyunsaturated fatty acid lipoxygenase ALOX15B
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mi...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...
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Polyunsaturated fatty acid lipoxygenase ALOX15B
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mi...
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Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 4.58E+4nM
Assay Description:
Inhibition of recombinant PTP1B
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Tyrosine-protein phosphatase non-receptor type 6
(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 6.54E+4nM
Assay Description:
Inhibition of recombinant SHP1
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Cocaine esterase
(Homo sapiens (Human))
Dalian Institute Of Chemical Physics
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 6.93E+4nM
Assay Description:
Inhibition of CE2 in human liver microsomes using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addition measured...
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Beta-glucuronidase
(Rattus norvegicus)
University Of Kwazulu-Natal
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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IC50: 9.72E+4nM
Assay Description:
Inhibition of rat liver beta-glucuronidase
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Pancreatic alpha-amylase
(Sus scrofa (Pig))
Dalian University of Technology
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: >2.00E+5nM
Assay Description:
Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mi...
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Aldo-keto reductase family 1 member B1
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
IC50: 2.80E+5nM
Assay Description:
Inhibition of reductase activity of N-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3) assessed as assessed as p...
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Tyrosine-protein phosphatase non-receptor type 7
(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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IC50: >3.00E+5nM
Assay Description:
Inhibition of recombinant HePTP
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Egl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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EC50: >5.00E+4nM
Assay Description:
Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha aft...
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Egl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
EC50: >5.00E+4nM
Assay Description:
Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha aft...
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Protein kinase C eta type
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50233538
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
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Affinity Data
Kd: 250nM
Assay Description:
Binding affinity to recombinant human PKCeta in after 2 hrs by microequilibrium dialysis assay
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