Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 47 hits in this display
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 100nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 100nMAssay Description:Inhibition of human HDAC2 expressed in Sf9 cells using p53 (379 to 382 residues) (Arg-His-Lys(Ac)-Lys(Ac)) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 100nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 257nMAssay Description:Inhibition of recombinant human HDAC3 using fluorescent as substrate measured for 15 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 322nMAssay Description:Inhibition of recombinant human HDAC2 using fluorescent as substrate measured for 30 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 460nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 500nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 500nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 500nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 500nMAssay Description:Inhibition of HDAC1 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys(Ac)-Lys(Ac)) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 1.33E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 1.42E+3nMAssay Description:Inhibition of recombinant human HDAC1 using fluorescent as substrate measured for 15 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 1.50E+3nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 1.50E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 2.83E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 3.97E+3nMAssay Description:Inhibition of recombinant human HDAC8 using fluorescent as substrate measured for 10 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 9.00E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys(Ac)-Lys(Ac)) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 9.09E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 9.10E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 9.10E+3nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 1.53E+4nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 1.89E+4nMAssay Description:Inhibition of recombinant human HDAC6 using fluorescent as substrate measured for 10 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: 4.45E+4nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC4 using fluorescent as substrate measured for 30 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC5 using fluorescent as substrate measured for 30 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: >1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: >1.00E+5nMAssay Description:Inhibition of human HDAC4 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: >1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: >1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
BDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
IC50: >1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair