Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 187 hits in this display
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Ki: 2.20nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Ki: 292nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Ki: 5.41E+3nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat brain membranes in presence of (+)-pentazocine by scintillation counting methodMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Transporter(Rattus norvegicus (rat))National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Transporter(Rattus norvegicus (rat))National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Ki: 5.01E+4nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
IC50: 3nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in human HEK293 cells incubated for 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
IC50: 5.80nMAssay Description:Inhibition of SERT (unknown origin) in HEK293 cells assessed as inhibition of 5-HT reuptake by spectrophotometric analysisMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
IC50: 6.30nMAssay Description:Inhibition of SERT (unknown origin) expressed in HEK293 cells assessed as reduction in 5-HT uptake incubated for 30 minsMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
IC50: 6.70nMAssay Description:Inhibition of [3H]5-HT uptake by SERT primary site (S1) (unknown origin) expressed in African green monkey COS1 cells after 10 mins by TopCount scint...More data for this Ligand-Target Pair
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
IC50: 19nMAssay Description:Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
IC50: 170nMAssay Description:Inhibition of [3H]5-HT uptake by SERT primary site (S1) (unknown origin) expressed in African green monkey COS1 cells after 10 mins by TopCount scint...More data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
IC50: 1.88E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
IC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
IC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
IC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
IC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
BDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
EC50: 8.70E+3nMAssay Description:Inhibition of [3H]-S-citalopram dissociation from SERT allosteric modulator site (S2) (unknown origin) expressed in African green monkey COS1 cell me...More data for this Ligand-Target Pair
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
EC50: 5.10E+3nMAssay Description:Inhibition of [3H]-S-citalopram dissociation from SERT allosteric modulator site (S2) (unknown origin) expressed in African green monkey COS1 cell me...More data for this Ligand-Target Pair
BDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Kd: 2.60nMAssay Description:Binding affinity to human SERT expressed in African green monkey COS7 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
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