Found 13 Enz. Inhib. hit(s) with Target = 'Sodium-dependent serotonin transporter' and Ligand = 'BDBM50302225' TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 0.890nMAssay Description:Displacement of [3H]citalopram from SERT in rat brain stem by scintillation countingMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 1nMAssay Description:Displacement of [3H](R,S)-citalopram HBr from human SERTMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Displacement of [125I]-RTI-55 from human SERT expressed in HEK293 cell membranes after 1 hr by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.40nMAssay Description:Inhibition of 5-hydroxy[3H]tryptamine uptake at human SERT expressed in African green monkey COS7 cells incubated for 10 mins prior to radioligand ad...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of [3H]5-HT uptake by SERT primary site (S1) (unknown origin) expressed in African green monkey COS1 cells after 10 mins by TopCount scint...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]-S-citalopram from human SERT primary site (S1) expressed in African green monkey COS7 cell membranes after 2 hrs by microbeta sc...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Allosteric modulation at wild-type human SERT site S2 expressed in african green monkey COS7 cells assessed as inhibition of [3H]citalopram dissociat...More data for this Ligand-Target Pair
Affinity DataEC50: 5.80E+3nMAssay Description:Inhibition of [3H]-S-citalopram dissociation from human SERT allosteric modulator site (S2) expressed in African green monkey COS7 cell membranes aft...More data for this Ligand-Target Pair
Affinity DataKd: 2.60nMAssay Description:Binding affinity to human SERT expressed in African green monkey COS7 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 5.10E+3nMAssay Description:Inhibition of [3H]-S-citalopram dissociation from SERT allosteric modulator site (S2) (unknown origin) expressed in African green monkey COS1 cell me...More data for this Ligand-Target Pair
