Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 24 hits in this display
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
Ki: 84nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
Ki: 92nMAssay Description:Displacement of Thio-T from amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
Ki: 262nMAssay Description:Displacement of Thio-T from human recombinant tau (243 to 375) expressed in Escherichia coli BL21(DE3)RIL after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
IC50: 4.60E+3nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...More data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
IC50: 4.70E+3nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...More data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
IC50: 1.94E+4nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
IC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
IC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
IC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
BDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)