Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 18 hits in this display
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
Ki: 0.470nM ΔG°: -54.1kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 were determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
Ki: 0.470nM ΔG°: -54.1kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 were determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
Ki: 4.88nM ΔG°: -48.2kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 were determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
Ki: 4.88nM ΔG°: -48.2kJ/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay was used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay monit...More data for this Ligand-Target Pair
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
Ki: 1.75E+3nMpH: 5.0Assay Description:This assay monitored the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY...More data for this Ligand-Target Pair
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
IC50: 1.90nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
IC50: 1.90nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)
IC50: >1.00E+5nMAssay Description:Inhibition of human Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-PheArg-Leu-Lys(Dnp)-D-Arg-NH2 as substrate after 45 minsMore data for this Ligand-Target Pair