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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
89
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 0.5nM
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 0.603nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor entirely in guinea pig ileum
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 1.30nM
Assay Description:
pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 1.30nM
Assay Description:
Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-a...
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 1.30nM
Assay Description:
In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 3A
(RAT)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 1.60nM
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 1.60nM
Assay Description:
Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluated
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 1.60nM
Assay Description:
In vitro by displacement of [3H]LY-278584 from 5-hydroxytryptamine 3 receptor on rat entorhinal cortex
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 1.60nM
Assay Description:
In vitro affinity for 5-hydroxytryptamine 3 (5-HT3) receptor by displacement of [3H]BRL-43694 from rat entorhinal cortex
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 1.70nM
Assay Description:
Concentration that inhibits the binding of radioligand, [3H]-ICS 205930, to 5-hydroxytryptamine 3 receptor from rat cortex
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70nM
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 1.99nM
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 2nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazine
Checked by Author
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 2.70nM
Assay Description:
In vitro binding affinity for the 5-hydroxytryptamine 3 receptor was determined with NG-108-15 mouse neuroblastoma-glioma cells
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 2.70nM
Assay Description:
In vitro inhibition of rat liver dihydrofolate reductase.
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 2.70nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cells
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Target
5-hydroxytryptamine receptor 3A
(RAT)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 2.80nM
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 2.80nM
Assay Description:
Binding affinity at 5HT3 receptor
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagus
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 3.80nM
Assay Description:
Displacement of binding of [3H]-BRL 43694 to 5-hydroxytryptamine 3 receptor in rat cerebral cortex
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 3.80nM
Assay Description:
The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 5.30nM
Assay Description:
Inhibition of 5HT3 receptor
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Organon Laboratories
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 5.30nM
Assay Description:
Inhibition constant against 5-hydroxytryptamine 1A receptor
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Organon Laboratories
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 6.90nM
Assay Description:
Inhibition constant against nicotinic acetylcholine receptor alpha7
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 6.90nM
Assay Description:
In vitro Binding affinity towards alpha-7 nAChR was determined
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Organon Laboratories
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 6.90nM
Assay Description:
Binding affinity to alpha7 nAChR
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Target
5-hydroxytryptamine receptor 3A
(GUINEA PIG)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 8.41nM
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Target
5-hydroxytryptamine receptor 3A/3B/3C/3D/3E
(Homo sapiens (Human))
Cooperation Pharmaceutique Fran�Aise
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 33nM
Assay Description:
Binding affinity of compound towards 5-hydroxytryptamine 3 receptor using [3H]-BRL-43694 (1 nM) ligand in NG cells 108-15 was determined
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 63nM
Assay Description:
Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptor
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 63.1nM
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 63.1nM
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 63.1nM
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 63.1nM
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
Copy InChI
Affinity Data
Ki: 63.1nM
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Target
5-hydroxytryptamine receptor 4
(Homo sapiens (Human))
University of Oslo
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 79.4nM
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Target
5-hydroxytryptamine receptor 4
(MOUSE)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 87.1nM
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Ki: 100nM
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Target
Soluble acetylcholine receptor
(Aplysia Californica)
Uc San Diego
Ligand
BDBM91594
(Tropisetron)
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Affinity Data
Ki: 109nM ΔG°: -39.1kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 125nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 4 receptor in striatum membranes of guinea-pig brain was evaluated
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Target
5-hydroxytryptamine receptor 4
(MOUSE)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 158nM
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Target
5-hydroxytryptamine receptor 4
(MOUSE)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 158nM
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Target
5-hydroxytryptamine receptor 4
(MOUSE)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 158nM
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Target
5-hydroxytryptamine receptor 4
(Homo sapiens (Human))
University of Oslo
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 158nM
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 159nM
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Target
5-hydroxytryptamine receptor 4
(Homo sapiens (Human))
University of Oslo
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 200nM
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Target
5-hydroxytryptamine receptor 4
(Homo sapiens (Human))
University of Oslo
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 200nM
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 200nM
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Target
5-hydroxytryptamine receptor 4
(Homo sapiens (Human))
University of Oslo
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
Copy InChI
Affinity Data
Ki: 200nM
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 251nM
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 501nM
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 501nM
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
Copy InChI
Affinity Data
Ki: 544nM
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: 544nM
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Displacement of binding of [3H]-5-HT to 5-hydroxytryptamine 1 receptor in rat cerebral cortex
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Target
5-hydroxytryptamine receptor 2B
(BOVINE)
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Ki: 2.60E+3nM
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Target
5-hydroxytryptamine receptor 3A
(GUINEA PIG)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 4.33E+3nM
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3D Structure (crystal)
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: 5.61E+3nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Organon Laboratories
Curated by
ChEMBL
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: >1.00E+4nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
U. 109
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 3A
(GUINEA PIG)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human))
Veterans Affairs Medical Center
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1A/1B/1D/2C
(Homo sapiens (Human))
University of Heidelberg
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
University of Texas
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1E
(Homo sapiens (Human))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
Seattle Veterans Affairs Medical Center
Curated by
PDSP K
i
Database
Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
Copy SMILES
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Ki: >1.00E+4nM
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Target
5-hydroxytryptamine 1D receptor
(Bos taurus (Bovine))
Albany Medical College
Curated by
PDSP K
i
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Ligand
BDBM50007871
(CHEMBL8197 | ICS 205-930 | TROPISETRON)
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Affinity Data
Ki: >1.00E+4nM
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Target
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 1.60E+4nM
Assay Description:
In vitro Binding affinity towards alpha-3 (PC12) nAChR was determined
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Target
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 2.70E+4nM
Assay Description:
In vitro Binding affinity towards alpha-1-beta-1-gamma delta nAChR was determined
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Ki: 5.50E+4nM
Assay Description:
In vitro Binding affinity towards 5-hydroxytryptamine 3 receptor was determined
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
IC50: 1.30nM
Assay Description:
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
IC50: 1.40nM
Assay Description:
Inhibition of 5-HT (1 ug/mL) induced depolarization in rat vagus nerve (5-hydroxytryptamine 3 receptor antagonism)
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
IC50: 2.30nM
Assay Description:
Binding affinity was evaluated in vitro by displacement of [3H]zacopride radioligand from 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
IC50: 3.10nM
Assay Description:
Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 3 receptor
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Universidad De Alcal£
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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IC50: >1.00E+3nM
Assay Description:
Binding affinity towards Dopamine receptor D2 in rat was evaluated
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Homo sapiens (Human))
University Of Florida
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Antagonism of ACh response at Nicotinic acetylcholine receptor alpha4-beta2 expressed in xenopus oocytes
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
IC50: 3.16E+3nM
Assay Description:
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP)
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
IC50: 1.70E+5nM
Assay Description:
Antagonism of ACh response at Nicotinic acetylcholine receptor alpha4-beta2 expressed in xenopus oocytes
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Target
5-hydroxytryptamine receptor 3A/3B
(Mus musculus (house mouse))
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Kd: 0.813nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagus
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Target
5-hydroxytryptamine receptor 3A/3B
(Mus musculus (house mouse))
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
Kd: 0.794nM
Assay Description:
Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated perfused rabbit heart (RH)
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Florida
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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Affinity Data
EC50: 10nM
Assay Description:
Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-7 expressed in xenopus oocytes
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Organon Laboratories
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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EC50: 1.30E+3nM
Assay Description:
Agonist activity at alpha7 nAChR
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Organon Laboratories
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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EC50: 1.30E+3nM
Assay Description:
Effective concentration that causes inhibition of alpha-7 nAChR, was determined. Values are expressed as EC50 +/- SEM.
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Florida
Curated by
ChEMBL
Ligand
BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
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EC50: 1.30E+3nM
Assay Description:
Partial agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Organon Laboratories
Curated by
ChEMBL
Ligand
BDBM91594
(Tropisetron)
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Affinity Data
EC50: 92nM
pH: 7.4 T: 2°C
Assay Description:
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...
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