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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
21
hits in this display
Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 2.60nM
Assay Description:
Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated perfused rabbit heart (RH)
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 2.60nM
Assay Description:
Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]-BRL-43694 displacement.
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 2.60nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligand
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor was determined in rat cerebro cortical membranes using [3H]quipazine.
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazine
Checked by Author
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 3.70nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 3 receptor by displacement of racemic [3H]zacopride from rat cortex
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
TBA
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 5nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 3 receptor by displacement of [3H](R)-zacopride from ondansetron-treated NG-108-15 cell membranes
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 8nM
Assay Description:
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
University of Alberta
Curated by
PDSP K
i
Database
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 200nM
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
University of Alberta
Curated by
PDSP K
i
Database
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 251nM
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 415nM
Assay Description:
The ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brain
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Target
5-hydroxytryptamine receptor 4
(RAT)
Cnrs-Biocis
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 1.51E+3nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
University of Alberta
Curated by
PDSP K
i
Database
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 2.82E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 4 receptor by displacement of [3H]GR-113808 from guinea pig brain striatum.
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The ability to inhibit [3H]5-HT binding to 5-hydroxytryptamine 1 receptor in rat cortex
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brain
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Target
D(1A) dopamine receptor
(RAT)
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The ability to inhibit [3H]rauwolscine binding to alpha-2 adrenergic receptor in rat cortex
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Target
Beta-1/Beta-2/Beta-3 adrenergic receptor
(Rattus norvegicus (Rat))
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The ability to inhibit [3H]dihydroalprenolol prenolol binding to Beta adrenergic receptor in rat whole brain
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The ability to inhibit [3H]domperidone binding to dopamine receptor D2 in rat striata
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Target
5-hydroxytryptamine receptor 4
(RAT)
Cnrs-Biocis
Curated by
ChEMBL
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
EC50: 501nM
Assay Description:
5-hydroxytryptamine 4 receptor agonist activity in the rat esophageal muscularis mucosae
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
University of Alberta
Curated by
PDSP K
i
Database
Ligand
BDBM50031475
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
EC50: 166nM
Assay Description:
5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...
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