Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 77 hits in this display   

TargetCytochrome P450 1B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKi:  44nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 4-estradiol as substrate in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKi:  289nMAssay Description:Inhibition of electric eel AChE by enzyme kinetics assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKi:  730nMAssay Description:Binding affinity to PPARalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholinesterase(Equus caballus (Horse))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of horse serum BChE by enzyme kinetics assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKi:  1.43E+4nMAssay Description:Inhibition of neuraminidase in influenza A virus (A/Puerto Rico/8/1934(H1N1)) pre-incubated for 30 mins before NA-Star substrate addition for 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(+) hydrolase SARM1(Homo sapiens)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKi:  1.30E+5nMAssay Description:Noncompetitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortase family protein(Staphylococcus aureus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of beta-hematin formation after 18 hrs by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSortase family protein(Staphylococcus aureus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  12nMAssay Description:Inhibition of beta-hematin formation after 18 hrs by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  40nMAssay Description:Inhibition of AChE assessed as hydrolysis of acetylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha cell membranes coexpressing human NADPH-cytochrome P450 reductase using 7-Ethoxyres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  100nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine as substrate assessed as substrate hydrolysis by spectrophotometric/Ellman methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  330nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as inhibition of CpGB-induced NF-kappaB activation after 24 hrs by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  374nMAssay Description:Inhibition of electric eel AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  374nMAssay Description:Inhibition of electric eel AChE by modified Ellman methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  374nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  374nMAssay Description:Inhibition of electric eel AChE using acetylcholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  374nMAssay Description:Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  374nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride substrate as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  374nMAssay Description:Inhibition of electric eel AcetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  374nMAssay Description:Inhibition of electric eel AChE after 15 mins by Ellman's method using acetylcholine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  610nMAssay Description:Inhibition of human AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  770nMpH: 8.0 T: 2°CAssay Description:Briefly, 140 μL of sodium phosphate buffer (pH 8.0), 20 μL of each tested compound with different concentrations (4, 20, and 100 μM) a...More data for this Ligand-Target Pair
In DepthDetails
TargetCholinesterase(Homo sapiens (Human))
Catholic University Of Daegu

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of BChE (unknown origin) using butyrylthiocholine as substrate assessed as substrate hydrolysis by spectrophotometric/Ellman methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of CYP1B1 in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  2.74E+3nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  4.08E+3nMAssay Description:Inhibition of N-terminal His-tagged human AKR1C3 (1 to 323 residues) expressed in Escherichia coli using 4-adione as substrate in presence of NADPH b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek7(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of purified recombinant human NEK7 incubated for 15 mins before ATP and substrate addition and further incubated for 40 mins by ADPGlo kin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Beijing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  6.97E+3nMAssay Description:Inhibition of recombinant LSD1 (unknown origin) expressed in Escherichia coli BL21 using H3K4me2 as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 8(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  7.66E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 8(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  7.66E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCholinesterase(Equus caballus (Horse))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine chloride as substrate incubated for 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division protein FtsZ(Staphylococcus aureus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Staphylococcus aureus recombinant FTsZ preincubated for 10 mins followed by compound addition measured after 30 mins by Cytophos phosph...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCell division protein FtsZ(Escherichia coli)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli K12 FtsZ assembly by light-scattering assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division protein FtsZ(Escherichia coli)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of recombinant Escherichia coli K12 FtsZ GTPase activity by malachite green sodium molybdate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.74E+4nMAssay Description:Inhibition of recombinant human acetylcholinesterase using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of equine serum BuChE using butyrylcholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of horse serum BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of equine serum BuChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Guangzhou Institute Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Guangzhou Institute Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of equine BChE after 15 mins by Ellman's method using acetylcholine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Guangzhou Institute Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of equine serum ButyrylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of equine serum BChE using butylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Catholic University Of Daegu

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of BChE assessed as hydrolysis of butrylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortase family protein(Staphylococcus aureus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  2.58E+4nMAssay Description:Inhibition of SrtAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Catholic University Of Daegu

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  3.07E+4nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (strain A/USSR/90/1977 H1N1))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  3.22E+4nMAssay Description:Inhibition of Influenza A virus H5N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Tianjin Key Laboratory On Technologies Enabling Development Of Clinical Therapeutics And Diagnostics

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of telomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (strain A/USSR/90/1977 H1N1))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  3.85E+4nMAssay Description:Inhibition of recombinant Influenza A virus H1N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Catholic University Of Daegu

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  4.72E+4nMAssay Description:Inhibition of human butyrylcholinesterase in plasma using butyrylthiocholineiodide as substrate preincubated with enzyme for 5 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-8(Homo sapiens (Human))TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  5.00E+4nMAssay Description:Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  6.61E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(+) hydrolase SARM1(Homo sapiens)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  7.70E+4nMAssay Description:Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Expi293 cells lysates using ENAD as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortase family protein(Staphylococcus aureus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.02E+5nMAssay Description:Inhibition of Staphylococcus aureus sortase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(+) hydrolase SARM1(Homo sapiens)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortase family protein(Staphylococcus aureus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of Staphylococcus aureus SrtA using dabcyl-QALPETGEE-edans as substrate preincubated for 1 hr followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortase family protein(Staphylococcus aureus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of Staphylococcus aureus SrtA using dabcyl-QALPETGEE-edans as substrate preincubated for 1 hr followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortase family protein(Staphylococcus aureus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.21E+5nMAssay Description:Inhibition of Staphylococcus aureus ATCC 6538p sortase A expressed in Escherichia coli using dabcyl-QALPETGEE-edans as substrate incubated for 1 hr b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(+) hydrolase SARM1(Homo sapiens)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.40E+5nMAssay Description:Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(+) hydrolase SARM1(Homo sapiens)
Umass Medical School

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.40E+5nMAssay Description:Inhibition of purified human SARM1 TIR domain (561 to 724 residues) using ENAD as substrate preincubated for 20 mins followed by ENAD addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.42E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.42E+5nMAssay Description:Inhibition of recombinant human Prolyl oligopeptidase expressed in Escherichia coli expression system using (Z)-Gly-Pro-p-nitroanilide as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.45E+5nMAssay Description:Inhibition of recombinant human His-tagged Prolyl oligopeptidase expressed in Escherichia coli expression system preincubated with enzyme for 15 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.45E+5nMAssay Description:Inhibition of POP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  1.45E+5nMAssay Description:Inhibition of human recombinant POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  2.97E+5nMAssay Description:Inhibition of Human immunodeficiency virus 1 NL4.3 reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  2.97E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt-activated lipase(Bos taurus)TBA
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataIC50:  3.15E+5nMAssay Description:Inhibition of Sus scrofa (pig) pancreatic lipase type 2 using PNPB as substrate pre-incubated with enzyme for 5 min prior to substrate addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataEC50:  580nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek7(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKd:  1.56E+4nMAssay Description:Binding affinity to purified recombinant human NEK7 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKd:  2.48E+4nMAssay Description:Binding affinity to His-tagged RXRalpha LBD (unknown origin) expressed in Escherichia coli strain BL21 (DE3) by fluorescence quenching analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCell division protein FtsZ(Escherichia coli)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50203126(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Affinity DataKd:  23nMAssay Description:Displacement of bis-ANS from Escherichia coli FtsZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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