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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
93
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 0.370nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cell membranes after 30 mins
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.372nM
Assay Description:
Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in human HeLa cell membranes after 30 mins by liquid scintillation coun...
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.372nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed in human HeLa cells incubated for 30 mins by radioligand competition ...
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.372nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in human HeLa cells
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.460nM
Assay Description:
Binding affinity for human 5-hydroxytryptamine 1A receptor
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
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Affinity Data
Ki: 0.778nM
Assay Description:
Binding affinity towards human Alpha-1D adrenergic receptor
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.800nM
Assay Description:
Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli...
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
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Affinity Data
Ki: 0.933nM
Assay Description:
Displacement of [3H]8-hydroxy-2-(di-n-propylamino)tetralin from human 5-hydroxytryptamine 1A receptor
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Target
Alpha-1D adrenergic receptor
(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 0.959nM
Assay Description:
In vitro functional activity at Alpha-1A adrenergic receptor in rat vas deferens
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.05nM
Assay Description:
Binding affinity to adrenergic Alpha-1D receptor
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.26nM
Assay Description:
Displacement of [3H]-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cells after 30 mins by liquid scintillation counting
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.26nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in human HeLa cells
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.26nM
Assay Description:
Displacement [3H]8-OH-DPAT of human cloned 5HT1A receptor expressed in human HeLa cells by rapid filtration technique
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.29nM
Assay Description:
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
More data for this Ligand-Target Pair
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.29nM
Assay Description:
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.29nM
Assay Description:
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoreceptor expressed in CHO cells after 30 mins by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.29nM
Assay Description:
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
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Copy BDB DOI
Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.30nM
Assay Description:
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
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Ligand Info
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CHEMBL
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.30nM
Assay Description:
Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HeLa cell membranes after 30 mins by TopCount liquid scintillation ...
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.30nM
Assay Description:
Displacement of [3H]prazosin from recombinant human alpha-1d adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.30nM
Assay Description:
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scin...
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.30nM
Assay Description:
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competit...
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.30nM
Assay Description:
Inhibitory constant value against the 5-hydroxytryptamine 1A receptor
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
More data for this Ligand-Target Pair
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.60nM
Assay Description:
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adren...
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.60nM
Assay Description:
Binding affinity for human Alpha-1D adrenergic receptor
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70nM
Assay Description:
Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
University Of Camerino
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70nM
Assay Description:
Binding affinity to human 5-HT1A receptor
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by
PDSP K
i
Database
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 1.99nM
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Target
Alpha-1D adrenergic receptor
(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
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Affinity Data
Ki: 2.40nM
Assay Description:
Compound was evaluated for its ability to displace [125I]-HEAT binding from rat Alpha-1D adrenergic receptor
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.51nM
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
Lundbeck Research Usa
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 3.10nM
Assay Description:
Binding affinity for rat Dopamine receptor D3
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.30nM
Assay Description:
In vitro binding affinity at human Alpha-1D adrenergic receptor.
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by
PDSP K
i
Database
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.20nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]-8-OH-DPAT
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Target
Alpha-1D adrenergic receptor
(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 8.60nM
Assay Description:
Binding affinity to the adrenergic receptor alpha-1D of rat aorta
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Lundbeck Research Usa
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 14nM
Assay Description:
Binding affinity for human Dopamine receptor D2
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 42.7nM
Assay Description:
Binding affinity to adrenergic alpha1A receptor
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Target
Alpha-1A adrenergic receptor
(CALF)
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 43nM
Assay Description:
Binding affinity towards bovine Alpha-1A adrenergic receptor
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
University Of Bologna
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 48nM
Assay Description:
Antagonistic affinity against rat striatum Dopamine receptor D2
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
University Of Bologna
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 49nM
Assay Description:
Displacement of [3H]spiperone from rat brain Dopamine receptor D2
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 50.1nM
Assay Description:
Binding affinity to adrenergic Alpha-1B receptor
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Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 69nM
Assay Description:
Displacement of [3H]prazosin from human cloned Alpha-1B adrenergic receptor
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by
PDSP K
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 79nM
Assay Description:
Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by
PDSP K
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 79.4nM
Assay Description:
Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement
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Target
Alpha-1A adrenergic receptor
(PIG)
Uppsala University
Curated by
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 79.4nM
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Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 94nM
Assay Description:
Binding affinity towards human Alpha-1B adrenergic receptor
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 112nM
Assay Description:
In vitro functional activity at Alpha-1B adrenergic receptor in rat spleen
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 130nM
Assay Description:
Binding affinity for human Alpha-1A adrenergic receptor
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Target
Alpha-1A adrenergic receptor
(PIG)
Uppsala University
Curated by
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 158nM
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Alpha-1B adrenergic receptor
(PIG)
Uppsala University
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 158nM
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 168nM
Assay Description:
Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 191nM
Assay Description:
Binding affinity for human Alpha-1B adrenergic receptor
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 191nM
Assay Description:
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1B adren...
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Target
5-hydroxytryptamine receptor 2C
(PIG)
Institut De Recherches Servier
Curated by
PDSP K
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 234nM
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 250nM
Assay Description:
Binding constant measured against Alpha-1A adrenergic receptor in human prostate; +:inactive
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 251nM
Assay Description:
In vitro binding affinity at human Alpha-1A adrenergic receptor.
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 290nM
Assay Description:
Binding affinity for human Alpha-1A adrenergic receptor
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 294nM
Assay Description:
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1A adren...
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Target
Alpha-1B adrenergic receptor
(Rattus norvegicus (rat))
Merck
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 328nM
Assay Description:
Compound was evaluated for its ability to displace [125I]-HEAT binding from rat Alpha-1B adrenergic receptor
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]prazosin from human cloned Alpha-1A adrenergic receptor
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]prazosin from human recombinant alpha1A adrenergic receptor expressed in CHO cell membranes after 30 mins
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]prazosin from recombinant human alpha-1a adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]Prazosin from human recombinant alpha 1A adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competit...
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement [3H]prazosin of human recombinant alpha1A adrenergic receptor expressed in CHO cells by rapid filtration technique
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]prazosin from human alpha1A adrenergic receptor expressed in CHO cells
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]prazosin from human cloned alpha1A adrenoceptor expressed in CHO cells
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]prazosin from human recombinant alpha1A adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 389nM
Assay Description:
Displacement of [3H]prazosin from recombinant human alpha1a adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scin...
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Target
Alpha-1B adrenergic receptor
(PIG)
Uppsala University
Curated by
PDSP K
i
Database
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 398nM
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Serotonin 2 (5-HT2) receptor
(RAT)
University Of Bologna
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 490nM
Assay Description:
Displacement of [3H]ketanserin from rat brain 5-hydroxytryptamine 2 receptor
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Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 495nM
Assay Description:
In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens.
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Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 525nM
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Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 620nM
Assay Description:
Compound was evaluated for its ability to displace [125I]-HEAT binding from rat Alpha-1A adrenergic receptor
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Alpha-1A adrenergic receptor
(PIG)
Uppsala University
Curated by
PDSP K
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Database
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 631nM
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Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 631nM
Assay Description:
In vitro binding affinity at human Alpha-1B adrenergic receptor.
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Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 708nM
Assay Description:
Displacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cells
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 708nM
Assay Description:
Displacement of [3H]prazosin from human cloned Alpha-1B adrenoreceptor expressed in CHO cells
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 708nM
Assay Description:
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
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Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 708nM
Assay Description:
Displacement [3H]prazosin of human recombinant Alpha-1B adrenergic receptor expressed in CHO cells by rapid filtration technique
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 708nM
Assay Description:
Displacement of [3H]prazosin from human recombinant alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins
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Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 708nM
Assay Description:
Displacement of [3H]prazosin from recombinant human alpha1b adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scin...
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Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 708nM
Assay Description:
Displacement of [3H]prazosin from recombinant human alpha-1b adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 708nM
Assay Description:
Displacement of [3H]Prazosin from human recombinant alpha 1B adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competit...
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Target
5-hydroxytryptamine receptor 3A
(RAT)
Institut De Recherches Servier
Curated by
PDSP K
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Database
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 1.00E+3nM
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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
University Of Bologna
Curated by
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 1.05E+3nM
Assay Description:
Antagonistic affinity against native rat cortex Alpha-2 adrenergic receptor
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
University Of Bologna
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
Ki: 1.18E+3nM
Assay Description:
Displacement of [3H]rauwolscine from rat brain Alpha-2 adrenergic receptor
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by
PDSP K
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: 1.74E+3nM
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5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Institut De Recherches Servier
Curated by
ChEMBL
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BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: >1.00E+4nM
Assay Description:
Binding affinity at 5-hydroxytryptamine 1B receptor
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5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Institut De Recherches Servier
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Ki: >1.00E+4nM
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5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by
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Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Affinity Data
IC50: 2.40nM
Assay Description:
Compound was evaluated for its ability to displace [3H]-8-OH-DPAT from serotonin 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes
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D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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IC50: 91nM
Assay Description:
Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranes
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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IC50: >1.00E+3nM
Assay Description:
Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranes
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Alpha-1D adrenergic receptor
(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
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Kd: 3.02nM
Assay Description:
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
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