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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
46
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM50167072
(CHEMBL3799125)
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Affinity Data
Ki: 0.0300nM
Assay Description:
Displacement of [3H]-CGP-12177 from human beta2-adrenergic receptor expressed in CHO cells after 60 mins by radioligand competition binding assay
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM50167072
(CHEMBL3799125)
Copy SMILES
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Affinity Data
Ki: 0.0340nM
Assay Description:
Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells
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Target
Beta-1 adrenergic receptor
(Mus musculus)
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM50167072
(CHEMBL3799125)
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Affinity Data
Ki: 0.210nM
Assay Description:
Displacement of [3H]-CGP-12177 from murine beta1-adrenergic receptor expressed in HEK293T cells after 60 mins by radioligand competition binding assa...
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
RzeszóW University Of Technology
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Affinity Data
Ki: 0.810nM
Assay Description:
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
Copy SMILES
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Affinity Data
Ki: 0.880nM
Assay Description:
Displacement of [3H]-CGP-12177 from human beta2-adrenergic receptor expressed in CHO cells after 60 mins by radioligand competition binding assay
More data for this Ligand-Target Pair
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.880nM
Assay Description:
Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Affinity Data
Ki: 1.10nM
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
UniversitÄT WÜRzburg
Curated by
PDSP K
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Database
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Ki: 1.70nM
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Rzesz£W University Of Technology
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Affinity Data
Ki: 2.20nM
Assay Description:
Displacement of [3H]Prazosin from alpha1 adrenergic receptor in Wistar rat cerebral cortex membrane by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Universit£
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement
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Target
Beta-1 adrenergic receptor
(Mus musculus)
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
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Affinity Data
Ki: 3.40nM
Assay Description:
Displacement of [3H]-CGP-12177 from murine beta1-adrenergic receptor expressed in HEK293T cells after 60 mins by radioligand competition binding assa...
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
Rzesz£W University Of Technology
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Ki: 3.40nM
Assay Description:
Displacement of [3H]Clonidine from alpha2 adrenergic receptor in Wistar rat cerebral cortex membrane by liquid scintillation counting
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
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Ki: 26nM
Assay Description:
Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50167072
(CHEMBL3799125)
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Affinity Data
Ki: 49nM
Assay Description:
Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
UniversitÄT WÜRzburg
Curated by
PDSP K
i
Database
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Ki: 247nM
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Target
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human))
University Of Helsinki
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
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Affinity Data
Ki: 1.30E+3nM
Assay Description:
Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation counting
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Orexin receptor type 2
(Homo sapiens (Human))
University Of Helsinki
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
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Affinity Data
Ki: 1.40E+3nM
Assay Description:
Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation counting
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Affinity Data
IC50: 350nM
Assay Description:
Inhibitory concentration against IKr potassium channel
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Orexin receptor type 2
(Homo sapiens (Human))
University Of Helsinki
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
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Affinity Data
IC50: 900nM
Assay Description:
Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation counting
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Target
Cytochrome P450 1B1
(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
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IC50: 1.10E+3nM
Assay Description:
Inhibition of human CYP1B1 using 7-ethyl-O-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assay
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Potassium channel subfamily K member 2
(Homo sapiens (Human))
Universit£
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Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 1.60E+3nM
Assay Description:
Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currents
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Target
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human))
University Of Helsinki
Curated by
ChEMBL
Ligand
BDBM50167073
(CHEMBL3798017)
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Affinity Data
IC50: 2.30E+3nM
Assay Description:
Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation counting
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Solute carrier family 22 member 1
(Homo sapiens (Human))
University Of California
Curated by
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Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 3.40E+3nM
Assay Description:
In vitro inhibition of geranylgeranyl-protein transferase type-I
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 4.60E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 6.00E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 6.60E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells
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Solute carrier family 22 member 2
(Homo sapiens (Human))
University Of California
Curated by
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Ligand
BDBM25759
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IC50: 7.50E+3nM
Assay Description:
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
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Potassium channel subfamily K member 10
(Homo sapiens (Human))
Universit£
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BDBM25759
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IC50: 7.60E+3nM
Assay Description:
Inhibition of of TREK2 (unknown origin) expressed in HEK293 cells assessed as reduction in channel currents
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
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BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 1.05E+4nM
Assay Description:
Inhibition of human Potassium channel HERG expressed in mammalian cells
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 1.05E+4nM
Assay Description:
Inhibitory concentration against potassium channel HERG
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 1.05E+4nM
Assay Description:
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique
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UDP-glucuronosyltransferase 1A1
(Homo sapiens (Human))
University Of Minnesota
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 1.20E+4nM
Assay Description:
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 1.26E+4nM
Assay Description:
Inhibition of human ERG
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Potassium channel subfamily K member 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 2.03E+4nM
Assay Description:
Inhibition of of human TREK1 expressed in oocytes assessed as reversible current depression
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Potassium channel subfamily K member 10
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 2.40E+4nM
Assay Description:
Inhibition of of TREK2 (unknown origin) expressed in oocytes assessed as reduction in channel currents
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UDP-glucuronosyltransferase 1A1
(Homo sapiens (Human))
University Of Minnesota
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 2.70E+4nM
Assay Description:
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
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Toll-like receptor 4
(Homo sapiens (Human))
School Of Pharmaceutical Sciences
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 3.22E+4nM
Assay Description:
Antagonist activity at human TLR4 expressed in HEK blue cells coexpressing MD-2/CD14 assessed as inhibition of LPS-induced NF-kappaB activation-media...
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Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: 9.24E+4nM
Assay Description:
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Beta-1 adrenergic receptor
(Homo sapiens (Human))
UniversitÄT WÜRzburg
Curated by
PDSP K
i
Database
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Kd: 1.76nM
pH: 7.4 T: 2°C
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
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Beta-2 adrenergic receptor
(Homo sapiens (Human))
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Kd: 0.400nM
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
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Beta-3 adrenergic receptor
(Homo sapiens (Human))
UniversitÄT WÜRzburg
Curated by
PDSP K
i
Database
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Kd: 5nM
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
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Beta-2 adrenergic receptor
(Homo sapiens (Human))
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)
Curated by
ChEMBL
Ligand
BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
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Affinity Data
Kd: 0.195nM
Assay Description:
Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintilla...
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