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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
18
hits in this display
Target
Casein kinase I isoform delta
(Homo sapiens (Human))
Christian-Albrechts University Of Kiel
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
Ki: 25nM
Assay Description:
Binding affinity to CK1delta (unknown origin)
More data for this Ligand-Target Pair
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Target
Casein kinase I isoform alpha
(Homo sapiens (Human))
Christian-Albrechts University Of Kiel
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
Ki: 501nM
Assay Description:
Binding affinity to CK1a1 (unknown origin)
More data for this Ligand-Target Pair
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Target
Mitogen-activated protein kinase 9
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of JNK2beta2 kinase
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
IC50: 18nM
Assay Description:
Inhibition of p56 Lck kinase
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
IC50: 34nM
Assay Description:
Inhibition against Mitogen-activated protein kinase p38 alpha
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 44nM
Assay Description:
Inhibition of p38alpha
Checked by Author
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
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Target
Mitogen-activated protein kinase 11
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
IC50: 44nM
Assay Description:
Inhibition of p38-beta MAP kinase
Checked by Author
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 44nM
Assay Description:
Inhibition of P38alphaMAPK (unknown origin)
More data for this Ligand-Target Pair
Target Info
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KEGG
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PDB
3D Structure (crystal)
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Target
Mitogen-activated protein kinase 11
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 44nM
Assay Description:
Inhibition of P38betaMAPK (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Dual specificity mitogen-activated protein kinase kinase 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
IC50: >50nM
Assay Description:
Inhibition of ERK2 kinase
More data for this Ligand-Target Pair
Target Info
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Target
Mitogen-activated protein kinase 8
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >50nM
Assay Description:
Inhibition of JNK1 kinase
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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Target
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
IC50: >50nM
Assay Description:
Inhibition of cRaf kinase
More data for this Ligand-Target Pair
Target Info
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Target
Cyclin-dependent kinase 1
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
IC50: >50nM
Assay Description:
Inhibition of cdc2 kinase
More data for this Ligand-Target Pair
Target Info
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
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Affinity Data
IC50: 83nM
Assay Description:
Inhibition of EGFR kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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CHEMBL
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Target
Protein kinase C alpha type
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Copy SMILES
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Affinity Data
IC50: 83nM
Assay Description:
Inhibition of PKCalpha kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
MCE
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.00E+4nM
Assay Description:
Inhibition of Raf1 kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 12
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of p38-gamma MAP kinase
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 13
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50105742
(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of p38delta MAP kinase
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI