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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
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Target
Neutrophil elastase
(Homo sapiens (Human))
Montana State University
Ligand
BDBM23705
(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
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Affinity Data
Ki: 45nM ΔG°: -41.9kJ/mole
pH: 7.5 T: 2°C
Assay Description:
HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...
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Target Info
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Target
Chymotrypsin-C
(Homo sapiens (Human))
Montana State University
Ligand
BDBM23705
(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
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Affinity Data
IC50: 15nM
Assay Description:
Chymotrypsin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentrati...
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Montana State University
Ligand
BDBM23705
(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
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Affinity Data
IC50: 1.70E+3nM
Assay Description:
Urokinase activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration ...
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Target
Prothrombin
(Homo sapiens (Human))
Montana State University
Ligand
BDBM23705
(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
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Affinity Data
IC50: 4.70E+3nM
Assay Description:
Thrombin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration o...
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Target
Plasma kallikrein
(Homo sapiens (Human))
Montana State University
Ligand
BDBM23705
(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
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Affinity Data
IC50: 6.20E+3nM
Assay Description:
Kallikrein activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration...
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Target
Cathepsin D
(Homo sapiens (Human))
Montana State University
Ligand
BDBM23705
(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
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Affinity Data
Assay Description:
Cathepsin D assays were monitored with a Fluoroskan Ascent FL microtiter plate reader at excitation and emission wavelengths of 340 and 390 nm, respe...
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Target Info
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KEGG
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Target
Aminopeptidase N
(Sus scrofa (Pig))
Montana State University
Ligand
BDBM23705
(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
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Affinity Data
Assay Description:
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...
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Target Info
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