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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Histamine H3 receptor
(Homo sapiens (Human))
Bioprojet-Biotech
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
Ki: 0.531nM
Assay Description:
Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assay
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Bioprojet-Biotech
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
Ki: 0.631nM
Assay Description:
Displacement of [3H]N-alpha-Methylhistamine from human recombinant H3 receptor expressed in HEK293 cells by competitive binding assay
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Bioprojet-Biotech
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
Ki: 1.70nM
Assay Description:
Inhibition of human H3 receptor
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Target
Histamine receptor H3
(Macaca mulatta (Rhesus macaque))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
Ki: 4.30nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in HEK293T cells
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Bioprojet-Biotech
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Copy InChI
Affinity Data
Ki: 6.80nM
Assay Description:
Binding affinity to recombinant human H3 receptor
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Bioprojet-Biotech
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.80nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO-K1 cells
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
Ki: 33nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor expressed in HEK293 cells coexpressed with CRE-beta-lactamase
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Bioprojet-Biotech
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO-K1 cells
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H2 receptor
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human histamine H2 receptor
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human histamine H1 receptor
More data for this Ligand-Target Pair
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]meth...
More data for this Ligand-Target Pair
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human histamine H4 receptor
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+4nM
Assay Description:
Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay
More data for this Ligand-Target Pair
Target Info
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
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Affinity Data
IC50: >2.10E+4nM
Assay Description:
Inhibition of CYP2C9
More data for this Ligand-Target Pair
Target Info
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Copy SMILES
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Affinity Data
IC50: >2.70E+4nM
Assay Description:
Inhibition of CYP2D6
More data for this Ligand-Target Pair
Target Info
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Copy SMILES
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Affinity Data
IC50: >2.70E+4nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Copy SMILES
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Affinity Data
IC50: >2.70E+4nM
Assay Description:
Inhibition of CYP1A2
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Cytochrome P450 2A6
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.70E+4nM
Assay Description:
Inhibition of CYP2A6
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM50262939
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.70E+4nM
Assay Description:
Inhibition of CYP2C19
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Ligand Info
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Copy BDB DOI