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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
47
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
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Affinity Data
Ki: 0.160nM
Assay Description:
Antagonist activity at recombinant human H3 receptor expressed in CHO-K1 cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.160nM
Assay Description:
Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]gammaS binding assay
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(GUINEA PIG)
Palack£
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
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Affinity Data
Ki: 0.160nM
Assay Description:
Inhibition of Guinea Pig Ileum H3R
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Target
Histamine H3 receptor
(GUINEA PIG)
Palack£
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.160nM
Assay Description:
Inhibition of Guinea Pig Ileum H3R
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(GUINEA PIG)
Palack£
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.160nM
Assay Description:
Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.300nM
Assay Description:
Inhibition of human H3 receptor
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.300nM
Assay Description:
Binding affinity to human H3R
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.300nM
Assay Description:
Binding affinity to human histamine H3 receptor
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.912nM
Assay Description:
Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assay
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.40nM
Assay Description:
Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in CHO-K1 cells
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.5nM
Assay Description:
Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assay
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.5nM
Assay Description:
Antagonist activity at histamine H3 receptor (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.70nM
Assay Description:
Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in rat C6 cells
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.70nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.70nM
Assay Description:
Displacement of [125I]iodoproxyfan human histamine H3 receptor
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.70nM
Assay Description:
Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.70nM
Assay Description:
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cells
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.70nM
Assay Description:
Displacement of [125I]-iodoproxyfan from human striatal full length H3 receptor after 60 mins by gamma counting method
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3nM
Assay Description:
Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from recombinant human histamine H3 receptor expressed in CHO-K1 cells assessed a...
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8nM
Assay Description:
Displacement of [3H]Nalpha-methylhistamine from recombinant human histamine H3 receptor stably transfected in HEK-293T cells membrane incubated for 9...
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
Assay Description:
Displacement of [3H]Nalpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cells incubated for 90 mins by competitio...
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
Assay Description:
Displacement of [3H]N-alpha-Methylhistamine from human recombinant H3 receptor expressed in HEK293 cells by competitive binding assay
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from human H3 receptor expressed in HEK-293 cell membrane after 90 mins by liquid scintillation counting ...
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 mins
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]N-alpha-Methylhistamine from recombinant human histamine H3 receptor expressed in human HEK293 cells incubated for 90 mins by mic...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]-N-alpha-methylhistamine from human recombinant full length H3R expressed in HEK293 cell membranes incubated for 90 mins by liqui...
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Mus musculus)
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
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Affinity Data
Ki: 14nM
Assay Description:
Displacement of [125I]-iodoproxyfan from mouse brain cortex H3 receptor after 60 mins by gamma counting method
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14.8nM
Assay Description:
Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
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Affinity Data
Ki: 17nM
Assay Description:
Binding affinity to rat histamine H3 receptor
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17nM
Assay Description:
Binding affinity to histamine H3 receptor in rat cerebral cortex
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17nM
Assay Description:
Displacement of [125I]-iodoproxyfan from rat brain cortex H3 receptor after 60 mins by gamma counting method
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17nM
Assay Description:
Binding affinity to rat H3R
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 28nM
Assay Description:
Displacement of [3]-RAMH from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation counting
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 30nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in CHO-K1 cells by microbeta scintillation analysi...
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
United Arab Emirates University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
Ki: 1.15E+3nM
Assay Description:
Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis
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Target
Histamine H4 receptor
(Homo sapiens (Human))
United Arab Emirates University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
Ki: <1.00E+4nM
Assay Description:
Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by li...
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
Ki: 1.34E+4nM
Assay Description:
Binding affinity to human H3 receptor assessed as inhibition constant incubated for 90 mins by scintillation counting method
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Copy BDB DOI
Target
Histamine H4 receptor
(Homo sapiens (Human))
United Arab Emirates University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of human H4 receptor
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Copy BDB DOI
Target
Histamine H4 receptor
(Homo sapiens (Human))
United Arab Emirates University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Binding affinity to human H4R
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
IC50: 12nM
Assay Description:
Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
IC50: 19nM
Assay Description:
Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of imetit-stimulation ERK1/2 phosphorylation by E...
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
IC50: 1.70E+3nM
Assay Description:
Inhibition of human ERG expressed in CHO cells at holding potential of -90 mV by patch clamp method
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Target
Cholinesterase
(Equus caballus (Horse))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
IC50: 8.40E+3nM
Assay Description:
Inhibition of equine serum BChE using BTCI as substrate incubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophoto...
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Target
Cholinesterase
(Equus caballus (Horse))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
IC50: 8.42E+3nM
Assay Description:
Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
Zhengzhou University
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
EC50: 8nM
Assay Description:
Inverse agonist activity at recombinant human histamine H3 receptor expressed in CHO-K1 cells preincubated for 10 mins followed by [35S]GTPgammaS add...
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Target
Histamine H3 receptor
(GUINEA PIG)
Palack£
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
Kd: 5.62nM
Assay Description:
Antagonist activity at histamine H3 receptor in isolated guinea pig ileum
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Copy BDB DOI
Target
Histamine H3 receptor
(GUINEA PIG)
Palack£
Curated by
ChEMBL
Ligand
BDBM50247053
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
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Affinity Data
EC50: 1.5nM
Assay Description:
Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay
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