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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
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Target
Histamine H4 receptor
(Homo sapiens (Human))
The Centre For Addiction and Mental Health
Curated by
PDSP K
i
Database
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
Ki: 402nM
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junion University
US Patent
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: <1.00E+3nM
Assay Description:
Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The mos...
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Target
Short transient receptor potential channel 5
(Mus musculus)
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of mouse TRPC5 expressed in thapsigargin treated HEK293/TREx cells assessed as reduction in intracellular calcium level in presence of GPC...
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Target Info
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3D Structure (crystal)
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Target
Heme oxygenase 2
(Rattus norvegicus (rat))
Queen'S University
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: 3.40E+3nM
Assay Description:
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...
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Target
Short transient receptor potential channel 4
(Mus musculus)
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: 6.40E+3nM
Assay Description:
Inhibition of YFP-tagged mouse TRPC4 beta expressed in thapsigargin treated HEK293 cells co-expressing M3 receptor assessed as reduction in carbachol...
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Target
Short transient receptor potential channel 3
(Homo sapiens (Human))
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: 9.10E+3nM
Assay Description:
Inhibition of YFP-tagged human TRPC3 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...
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Target
Short transient receptor potential channel 6
(Homo sapiens (Human))
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: 1.13E+4nM
Assay Description:
Inhibition of YFP-tagged human TRPC6 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...
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Target Info
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KEGG
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Target
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat))
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CFP-tagged rat TRPV1 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assay
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Target Info
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Target
Heat sensitive channel TRPV3
(Rattus norvegicus)
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of YFP-tagged rat TRPV3 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assay
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UniProtKB/TrEMBL
GoogleScholar
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Target
Transient receptor potential cation channel subfamily V member 4
(Mus musculus)
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of YFP-tagged mouse TRPV4 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assay
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
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Target
Transient receptor potential cation channel subfamily V member 2
(Rattus norvegicus)
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of YFP-tagged rat TRPV2 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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ChEBI
MCE
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PC sid
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In Depth
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Article
PubMed
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Target
Short transient receptor potential channel 7
(Mus musculus)
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: 2.65E+4nM
Assay Description:
Inhibition of YFP-tagged mouse TRPC7 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...
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Target Info
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KEGG
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ChEBI
MCE
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In Depth
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Article
PubMed
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Target
Heme oxygenase 1
(Rattus norvegicus (rat))
Queen'S University
Curated by
ChEMBL
Ligand
BDBM85747
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of HO-1 in Sprague-Dawley rat spleen microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas ch...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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ChEBI
MCE
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PC sid
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Patents
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In Depth
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Article
PubMed
Copy BDB DOI