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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 13 hits in this display   

TargetHistamine H4 receptor(Homo sapiens (Human))
The Centre For Addiction and Mental Health

Curated by PDSP Ki Database
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataKi:  402nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junion University

US Patent
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50: <1.00E+3nMAssay Description:Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The mos...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetShort transient receptor potential channel 5(Mus musculus)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of mouse TRPC5 expressed in thapsigargin treated HEK293/TREx cells assessed as reduction in intracellular calcium level in presence of GPC...More data for this Ligand-Target Pair
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 4(Mus musculus)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of YFP-tagged mouse TRPC4 beta expressed in thapsigargin treated HEK293 cells co-expressing M3 receptor assessed as reduction in carbachol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 3(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of YFP-tagged human TRPC3 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of YFP-tagged human TRPC6 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CFP-tagged rat TRPV1 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat sensitive channel TRPV3(Rattus norvegicus)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged rat TRPV3 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Mus musculus)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged mouse TRPV4 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 2(Rattus norvegicus)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged rat TRPV2 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 7(Mus musculus)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50:  2.65E+4nMAssay Description:Inhibition of YFP-tagged mouse TRPC7 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM85747(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HO-1 in Sprague-Dawley rat spleen microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas ch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed