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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
10
hits in this display
Target
Cathepsin S
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
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Affinity Data
IC50: 8nM
Assay Description:
The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Ligand Info
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US Patent
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Target
Cathepsin S
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
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Copy InChI
Affinity Data
IC50: 8.30nM
Assay Description:
Inhibition of human cathepsin S
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin S
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.30nM
Assay Description:
Inhibition of human cathepsin S by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin S
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9nM
Assay Description:
Inhibition of human cathepsin S by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin S
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9nM
Assay Description:
Inhibition of cathepsin S in human JY cells assessed as accumulation of lip10 by Western blot analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin K
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
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Copy InChI
Affinity Data
IC50: 178nM
Assay Description:
Inhibition of human cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin K
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 178nM
Assay Description:
Inhibition of human cathepsin K by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin L2
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human cathepsin V
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Procathepsin L
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human cathepsin L
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin B
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50323250
(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human cathepsin B
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI