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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  8nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  9nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of lip10 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  178nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  178nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin VMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed