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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
22
hits in this display
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50106240
(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
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Affinity Data
Ki: 9nM
Assay Description:
The compound was tested for inhibition of human urokinase type plasminogen activator (microPa)
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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Article
PubMed
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
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Affinity Data
Ki: 9nM ΔG°: -45.5kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
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Copy InChI
Affinity Data
Ki: 13nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Serine protease 1
(Bos taurus (bovine))
Celera
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
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Affinity Data
Ki: 100nM ΔG°: -39.6kJ/mole
pH: 7.72 T: 2°C
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
DrugBank
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Plasminogen
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
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Affinity Data
Ki: 110nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50106240
(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
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Copy InChI
Affinity Data
Ki: 110nM
Assay Description:
The compound was tested for inhibition of human plasmin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease 1/Trypsin-2
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50106240
(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
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Affinity Data
Ki: 230nM
Assay Description:
The compound was tested for inhibition of human trypsin
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease 1
(Bos taurus (bovine))
Celera
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
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Copy InChI
Affinity Data
Ki: 230nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
DrugBank
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Serine protease 1
(Homo sapiens (Human))
Celera
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 770nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor VII
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50106240
(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70E+3nM
Assay Description:
The compound was tested for inhibition of human coagulation factor VII
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease hepsin
(Homo sapiens (Human))
Celera
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.80E+3nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Urokinase-type plasminogen activator [179-431,I214M,N322A,S371A]
(Homo sapiens (Human))
Celera
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.40E+3nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.80E+3nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50106240
(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.80E+3nM
Assay Description:
The compound was tested for inhibition of human tissue plasminogen activator
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50106240
(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.90E+4nM
Assay Description:
Binding affinity against human coagulation factor X
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.90E+4nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.40E+4nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50106240
(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.00E+4nM
Assay Description:
The compound was tested for inhibition of human thrombin
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.00E+4nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14152
(6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.50E+4nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Serine protease hepsin
(Homo sapiens (Human))
Celera
Ligand
BDBM50106240
(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.60E+3nM
Assay Description:
Inhibition of recombinant human hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI