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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
27
hits in this display
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
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Affinity Data
Ki: 8nM
Assay Description:
Inhibitory concentration against Human Serine Protease Urokinase Plasminogen Activator
More data for this Ligand-Target Pair
Target Info
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MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Ligand Info
CHEMBL
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Article
PubMed
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8nM ΔG°: -45.7kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC sid
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8nM
Assay Description:
The compound was tested for inhibition of human urokinase type plasminogen activator (microPa)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
Serine protease 1
(Bos taurus (bovine))
Celera
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
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Affinity Data
Ki: 11nM ΔG°: -45.0kJ/mole
pH: 7.45 T: 2°C
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
DrugBank
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PC sid
PDB
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In Depth
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Article
PubMed
DrugBank
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 33nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
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Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 35nM
Assay Description:
Inihibtion of Human Serine Protease tissue type Plasminogen Activator
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 35nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 35nM
Assay Description:
The compound was tested for inhibition of human tissue plasminogen activator
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 72nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 78nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 78nM
Assay Description:
Binding affinity against human coagulation factor X
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 78nM
Assay Description:
Binding affinity against human coagulation factor X
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease hepsin
(Homo sapiens (Human))
Celera
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 85nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Ligand Info
DrugBank
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Plasminogen
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 100nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 100nM
Assay Description:
The compound was tested for inhibition of human plasmin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Plasminogen
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 100nM
Assay Description:
Inhibition of Human Serine Protease Plasmin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease 1/Trypsin-2
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 130nM
Assay Description:
The compound was tested for inhibition of human trypsin
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease 1
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 130nM
Assay Description:
Activity against Human Serine Protease Trypsin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease 1
(Bos taurus (bovine))
Celera
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 130nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
DrugBank
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 160nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor VII
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 160nM
Assay Description:
The compound was tested for inhibition of human coagulation factor VII
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease 1
(Homo sapiens (Human))
Axys Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 190nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 320nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 320nM
Assay Description:
The compound was tested for inhibition of human thrombin
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM50102780
(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 320nM
Assay Description:
Activity against Human Serine Protease Thrombin
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator [179-431,I214M,N322A,S371A]
(Homo sapiens (Human))
Celera
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 380nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
Axys Pharmaceutical
Ligand
BDBM14142
(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 760nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
DrugBank
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI