Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 18 hits in this display   

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50:  0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

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Ligand Info

In DepthDetails US Patent
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TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50:  0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50:  0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50:  0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetProcathepsin L(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin L2(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin S(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin K(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetPro-cathepsin H(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin B(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin F(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetProcathepsin L(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin L2(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin F(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin B(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetPro-cathepsin H(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin K(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin S(Homo sapiens (Human))
Cortexyme

US Patent

LigandBDBM453318(BDBM553824 | US10730826, Compound 18a)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails US Patent
Copy BDB DOI