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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50:  0.640nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50:  0.640nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin B(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50:  5.22E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin B(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50:  5.22E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin K(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50: >1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50: >1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50: >1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin K(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50: >1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50: >1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453290(US10730826, Compound 3a | US11325884, Compound 3a)
Affinity DataIC50: >1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent