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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
Prolyl endopeptidase
(Bos taurus)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
Ki: 0.210nM
Assay Description:
Inhibition of bovine brain POP
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Target
Prolyl endopeptidase
(Bos taurus)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
Ki: 0.350nM
Assay Description:
Inhibition of POP in bovine serum using Z-Gly-Pro-NH-Mec fluorimetric substrate
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Target
Prolyl endopeptidase
(Mus musculus)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
Ki: 0.350nM
Assay Description:
Inhibition of mouse brain POP
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Target
Prolyl endopeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
Ki: 0.400nM
Assay Description:
Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...
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Target
Prolyl endopeptidase
(Flavobacterium meningosepticum)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
Ki: 0.5nM
Assay Description:
Inhibition of Flavobacterium meningosepticum POP
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Target
Prolyl endopeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
Ki: 1nM
Assay Description:
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay
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Target
Prolyl endopeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
Ki: 4.30nM
Assay Description:
Inhibition of prolyl oligopeptidase
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Target
Prolyl endopeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
Ki: 8nM
Assay Description:
Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-p...
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Target
Prolyl endopeptidase
(Sus scrofa)
University Of Kuopio
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
IC50: 0.330nM
Assay Description:
In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pigbrain expressed
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Target
Prolyl endopeptidase
(Sus scrofa)
University Of Kuopio
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
IC50: 0.330nM
pH: 7.0
Assay Description:
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...
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Target
Prolyl endopeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
IC50: 1.10nM
Assay Description:
In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.
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Target
Prolyl endopeptidase
(Flavobacterium meningosepticum)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
IC50: 1.27nM
Assay Description:
Inhibition of Flavobacterium meningosepticum propyl endopeptidase
More data for this Ligand-Target Pair
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Target
Prolyl endopeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Copy InChI
Affinity Data
IC50: 2.80nM
Assay Description:
Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...
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Target
Chymotrypsin-like elastase family member 1
(Homo sapiens (Human))
Kyungpook National University
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
IC50: 51.6nM
Assay Description:
Inhibition of Flavobacterium meningosepticum PEP
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Target
Prolyl endopeptidase
(Rattus norvegicus)
Institut De Recherche Servier
Curated by
ChEMBL
Ligand
BDBM50038879
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
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Affinity Data
IC50: 54nM
Assay Description:
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex
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