TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Inhibition of rhodopsin kinase (unknown origin)More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of human GRK1 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 57.8nMAssay Description:Inhibition of human GRK1 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 70nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 78.1nMAssay Description:Inhibition of human GRK1 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Displacement of BODIPY TR-ADP from bovine GRK1 (1 to 535 residues) preincubated for 10 mins followed by compound addition and measured after 10 to 15...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human GRK1 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of GRK1-mediated bovine tubulin phosphorylation by scintillation countingMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of human GRK1 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of bovine GRK1 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of bovine GRK1 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of bovine C-terminal truncated GRK1 (535 residues) assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preinc...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human GRK1 using casein as substrateMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human GRK1More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human GRK1More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length human GRK1 using KKKKERLLDDRHD as substrate after 40 mins in presence of [gamma-33ATP] by radiometric scintilla...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.19E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Displacement of BODIPY TR-ADP from bovine GRK1 (1 to 535 residues) preincubated for 10 mins followed by compound addition and measured after 10 to 15...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.63E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Affinity DataIC50: 2.45E+4nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.58E+4nMAssay Description:Binding affinity towards serotonin transporter determined using [3H]paroxetine as radioligandMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibitory concentration against human alpha-L-fucosidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5.21E+4nMAssay Description:Inhibitory concentration against alpha-galactosidase of coffee beanMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 6.70E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 7.10E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair