Simple Search Results

Query String: ATM KO

CHEMBL1159714 Ko 707 BDBM50421719
3-((3S,6S)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-propionic acid tert-butyl ester BDBM50305083 3-((3S,6S,12aS)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-propionic acid tert-butyl ester Ko143 Ko-143 US9695174, Ko143 CHEMBL488910

Fuchss, T; Schiemann, K Imidazolonylquinolines and the use thereof as ATM kinase inhibitors US Patent US10457677 (2019)
Toledo-Sherman, LM; Dominguez, C; Breccia, P; Van De Poël, AJ; Wishart, G; Vater, HD; Esmieu, WR; Clissold, C; Blackaby, WP ATM kinase inhibitors and compositions and methods of use thereof US Patent US11685734 (2023)
ZHOU, D; CHENG, Z; WANG, Z SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF US Patent US20240207263 (2024)
Van de Poël, A; Toledo-Sherman, L; Breccia, P; Cachope, R; Bate, JR; Angulo-Herrera, I; Wishart, G; Matthews, KL; Martin, SL; Peacock, M; Barnard, A; Cox, HC; Jones, G; McAllister, G; Vater, H; Esmieu, W; Clissold, C; Lamers, M; Leonard, P; Jarvis, RE; Blackaby, W; Eznarriaga, M; Lazari, O; Yates, D; Rose, M; Jang, SW; Muñoz-Sanjuan, I; Dominguez, C Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease. J Med Chem 64: 5018-5036 (2021)
Fu, J; Wang, Y; Sun, Y; Wu, G; Lu, A; Zhang, S; Goodnow, R; Gilmer, T; Kastan, M; Kirsch, D Dual ATM and DNA-PK inhibitors for use in anti-tumor therapy US Patent US12187742 (2025)
Laufer, S; Forster, M; Dimitrov, T; Zender, L; Moschopoulou, A IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS US Patent US20230348462 (2023)
Small Molecular Inhibitors That Target ATM for Drug Discovery: Current Research and Potential Prospective.
Dimitrov, T; Anli, C; Moschopoulou, AA; Kronenberger, T; Kudolo, M; Geibel, C; Schwalm, MP; Knapp, S; Zender, L; Forster, M; Laufer, S Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Eur J Med Chem 235: (2022)
Barlaam, B; Cadogan, E; Campbell, A; Colclough, N; Dishington, A; Durant, S; Goldberg, K; Hassall, LA; Hughes, GD; MacFaul, PA; McGuire, TM; Pass, M; Patel, A; Pearson, S; Petersen, J; Pike, KG; Robb, G; Stratton, N; Xin, G; Zhai, B Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors. ACS Med Chem Lett 9: 809-814 (2018)
Dou, X; Sun, X; Huang, H; Jiang, L; Jin, Z; Liu, Y; Zou, Y; Li, Z; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Discovery of novel ataxia telangiectasia mutated (ATM) kinase modulators: Computational simulation, biological evaluation and cancer combinational chemotherapy study. Eur J Med Chem 233: (2022)
Degorce, SL; Barlaam, B; Cadogan, E; Dishington, A; Ducray, R; Glossop, SC; Hassall, LA; Lach, F; Lau, A; McGuire, TM; Nowak, T; Ouvry, G; Pike, KG; Thomason, AG Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase. J Med Chem 59: 6281-92 (2016)
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.
Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors.
Zhou, D; Cheng, Z 1-isopropyl-3-methyl-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c] cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (ATM) kinase and uses thereof US Patent US12226414 (2025)
Deng, D; Yang, Y; Zou, Y; Liu, K; Zhang, C; Tang, M; Yang, T; Chen, Y; Yuan, X; Guo, Y; Zhang, S; Si, W; Peng, B; Xu, Q; He, W; Xu, D; Xiang, M; Chen, L Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening. J Med Chem 66: 9495-9518 (2023)
Pike, KG; Barlaam, B; Cadogan, E; Campbell, A; Chen, Y; Colclough, N; Davies, NL; de-Almeida, C; Degorce, SL; Didelot, M; Dishington, A; Ducray, R; Durant, ST; Hassall, LA; Holmes, J; Hughes, GD; MacFaul, PA; Mulholland, KR; McGuire, TM; Ouvry, G; Pass, M; Robb, G; Stratton, N; Wang, Z; Wilson, J; Zhai, B; Zhao, K; Al-Huniti, N The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one). J Med Chem 61: 3823-3841 (2018)