Query String: NAC ALP
3-noradamantanecarboxylate (NAC) BDBM36211
ALP-POS-0c2c77e1-1 BDBM496453
ALP-POS-1245c3fa-1 BDBM495848
ALP-POS-1cbc2fae-1 BDBM628510
ALP-POS-1cbc2fae-2 BDBM628511
ALP-POS-3b848b35-2 BDBM496454
ALP-POS-477dc5b7-1 BDBM496234
ALP-POS-477dc5b7-5 BDBM496237
ALP-POS-6d04362c-2 BDBM496342
ALP-POS-6f6ae286-1 BDBM628517
ALP-POS-6f6ae286-3 BDBM628518
ALP-POS-6f6ae286-5 BDBM628519
ALP-POS-79636100-2 BDBM496079
ALP-POS-8b8a49e1-4 BDBM496181
ALP-POS-91609ae9-3 BDBM496573
ALP-POS-95b75b4d-5 BDBM496656
ALP-POS-a2344586-3 BDBM495354
ALP-POS-c3a96089-4 BDBM496064
ALP-POS-c59291d4-5 BDBM628210
ALP-POS-ce760d3f-2 BDBM495992
ALP-POS-f1807566-1 BDBM628496
ALP-UNI-3735e77e-1 BDBM495880
ALP-UNI-3735e77e-2 BDBM495881
ALP-UNI-b33a865d-1 BDBM496208
BDBM495524 ALP-POS-42f3de95-2
BDBM495643 ALP-POS-fe871b40-16
BDBM495722 ALP-UNI-3496895b-8
BDBM495884 ALP-POS-869ac754-1
BDBM495922 ALP-POS-305f6ec3-38
BDBM496047 ALP-POS-966f8da6-2
BDBM496101 ALP-POS-02c6a514-48
BDBM496161 ALP-POS-64a710fa-1
BDBM496162 ALP-POS-64a710fa-2
BDBM496182 ALP-POS-8b8a49e1-6
BDBM496235 ALP-POS-477dc5b7-2
BDBM496334 ALP-POS-a3de0cb1-16
BDBM496335 ALP-POS-8ed8d9ec-13
BDBM496336 ALP-POS-6747fa38-1
BDBM496565 ALP-POS-c0c213c9-9
BDBM496569 ALP-POS-c0c213c9-14
BDBM496591 ALP-POS-90c18d1d-1
BDBM628291 ALP-POS-477dc5b7-4
BDBM628484 ALP-POS-a577c8a2-1
BDBM628505 ALP-POS-6479a3a9-1
BDBM628525 ALP-POS-c56c1477-4
US12325697, Compound ALP-1 BDBM747580
ALP-POS-02c6a514-13 BDBM496088 CVD-0013864
ALP-POS-02c6a514-17 CVD-0013865 BDBM496089
ALP-POS-02c6a514-45 BDBM496099 CVD-0013876
ALP-POS-02c6a514-46 CVD-0013877 BDBM496100
ALP-POS-02c6a514-50 BDBM496103 CVD-0013880
ALP-POS-02c6a514-9 CVD-0013860 BDBM496085
ALP-POS-05819dc4-1 BDBM496461 CVD-0009923
ALP-POS-0c0a3b93-1 BDBM495602 CVD-0016332
ALP-POS-1cbc2fae-1 CVD-0018248 BDBM627796
ALP-POS-305f6ec3-11 BDBM495896 CVD-0014930
ALP-POS-305f6ec3-17 BDBM495902 CVD-0014936
ALP-POS-305f6ec3-18 CVD-0014937 BDBM495903
ALP-POS-305f6ec3-19 BDBM495904 CVD-0014938
ALP-POS-305f6ec3-21 CVD-0014940 BDBM495905
ALP-POS-305f6ec3-22 CVD-0014941 BDBM495906
ALP-POS-305f6ec3-23 BDBM495907 CVD-0014942
ALP-POS-305f6ec3-25 BDBM495909 CVD-0014944
ALP-POS-305f6ec3-29 CVD-0014948 BDBM495913
ALP-POS-305f6ec3-30 CVD-0014949 BDBM495914
ALP-POS-305f6ec3-31 CVD-0014950 BDBM495915
ALP-POS-305f6ec3-32 CVD-0014951 BDBM495916
ALP-POS-305f6ec3-33 CVD-0014952 BDBM495917
ALP-POS-305f6ec3-34 BDBM495918 CVD-0014953
ALP-POS-305f6ec3-4 CVD-0014923 BDBM495890
ALP-POS-305f6ec3-40 CVD-0014959 BDBM495924
ALP-POS-305f6ec3-41 CVD-0014960 BDBM495925
ALP-POS-305f6ec3-42 CVD-0014961 BDBM495926
ALP-POS-305f6ec3-43 CVD-0014962 BDBM495927
ALP-POS-305f6ec3-44 CVD-0014963 BDBM495928
ALP-POS-305f6ec3-45 BDBM495929 CVD-0014964
ALP-POS-305f6ec3-5 CVD-0014924 BDBM495891
ALP-POS-305f6ec3-50 BDBM495932 CVD-0014969
ALP-POS-305f6ec3-51 BDBM495933 CVD-0014970
ALP-POS-305f6ec3-52 CVD-0014971 BDBM495934
ALP-POS-305f6ec3-53 CVD-0014972 BDBM495935
ALP-POS-305f6ec3-55 CVD-0014974 BDBM495936
ALP-POS-305f6ec3-58 CVD-0014977 BDBM495939
ALP-POS-305f6ec3-7 CVD-0014926 BDBM495893
ALP-POS-5bb456a5-1 CVD-0015384 BDBM495772
ALP-POS-5bb456a5-7 CVD-0015390 BDBM495774
ALP-POS-6d04362c-4 BDBM496344 CVD-0012951
ALP-POS-6d96567b-2 BDBM495558 CVD-0016500
ALP-POS-6f6ae286-1 CVD-0018299 BDBM627631
ALP-POS-6f6ae286-3 CVD-0018301 BDBM627681
ALP-POS-6f6ae286-5 BDBM627808 CVD-0018303
ALP-POS-7c842ab8-1 BDBM496200 CVD-0013316
ALP-POS-88a7a97e-10 BDBM495655 CVD-0015721
ALP-POS-88a7a97e-19 CVD-0015730 BDBM495660
ALP-POS-88a7a97e-20 BDBM495661 CVD-0015731
ALP-POS-88a7a97e-30 BDBM495668 CVD-0015741
ALP-POS-88a7a97e-31 BDBM495669 CVD-0015742
ALP-POS-88a7a97e-32 BDBM495670 CVD-0015743
ALP-POS-88a7a97e-33 BDBM495671 CVD-0015744
ALP-POS-88a7a97e-41 BDBM495678 CVD-0015752
ALP-POS-88a7a97e-42 BDBM495679 CVD-0015753
ALP-POS-88a7a97e-43 BDBM495680 CVD-0015754
ALP-POS-902f21bb-2 CVD-0013894 BDBM496083
ALP-POS-95f71980-23 BDBM495539 CVD-0016532
ALP-POS-95f71980-24 BDBM495540 CVD-0016533
ALP-POS-95f71980-25 BDBM495541 CVD-0016534
ALP-POS-95f71980-38 BDBM495550 CVD-0016547
ALP-POS-a3de0cb1-10 BDBM496329 CVD-0013039
ALP-POS-b0bc6a46-13 BDBM496119 CVD-0013842
ALP-POS-b0bc6a46-14 BDBM496120 CVD-0013843
ALP-POS-b0bc6a46-16 CVD-0013845 BDBM496121
ALP-POS-b0bc6a46-17 CVD-0013846 BDBM496122
ALP-POS-b0bc6a46-18 CVD-0013847 BDBM496123
ALP-POS-b0bc6a46-2 BDBM496111 CVD-0013831
ALP-POS-b0bc6a46-24 BDBM496129 CVD-0013853
ALP-POS-b0bc6a46-25 BDBM496130 CVD-0013854
ALP-POS-b0bc6a46-26 BDBM496131 CVD-0013855
ALP-POS-b0bc6a46-27 CVD-0013856 BDBM496132
ALP-POS-b0bc6a46-28 CVD-0013857 BDBM496133
ALP-POS-b0bc6a46-29 CVD-0013858 BDBM496134
ALP-POS-b0bc6a46-4 BDBM496112 CVD-0013833
ALP-POS-b0bc6a46-5 CVD-0013834 BDBM496113
ALP-POS-c0c213c9-20 BDBM496572 CVD-0006337
ALP-POS-c0c213c9-3 CVD-0006320 BDBM496560
ALP-POS-c0c213c9-4 CVD-0006321 BDBM496561
ALP-POS-c0c213c9-5 CVD-0006322 BDBM496562
ALP-POS-c0c213c9-6 CVD-0006323 BDBM496563
ALP-POS-c0c213c9-7 CVD-0006324 BDBM496564
ALP-POS-c3a96089-1 BDBM496062 CVD-0014207
ALP-POS-c3a96089-2 BDBM496063 CVD-0014208
ALP-POS-ce760d3f-4 BDBM495994 CVD-0014505
ALP-POS-ced8ea4d-17 BDBM495737 CVD-0015453
ALP-POS-ced8ea4d-18 BDBM495738 CVD-0015454
ALP-POS-ced8ea4d-19 BDBM495739 CVD-0015455
ALP-POS-ced8ea4d-28 BDBM495748 CVD-0015464
ALP-POS-ced8ea4d-29 BDBM495749 CVD-0015465
ALP-POS-ced8ea4d-3 CVD-0015439 BDBM495725
ALP-POS-ced8ea4d-30 CVD-0015466 BDBM495750
ALP-POS-ced8ea4d-4 CVD-0015440 BDBM495726
ALP-POS-ced8ea4d-41 BDBM495759 CVD-0015477
ALP-POS-ced8ea4d-5 CVD-0015441 BDBM495727
ALP-POS-ced8ea4d-6 BDBM495728 CVD-0015442
ALP-POS-ced8ea4d-60 BDBM495769 CVD-0015496
ALP-POS-ced8ea4d-63 CVD-0015499 BDBM495770
ALP-POS-ced8ea4d-8 BDBM495729 CVD-0015444
ALP-POS-d0876c20-15 BDBM495613 CVD-0016288
ALP-POS-d0876c20-19 CVD-0016292 BDBM495615
ALP-POS-d0876c20-24 CVD-0016297 BDBM495618
ALP-POS-d0876c20-5 BDBM495608 CVD-0016278
ALP-POS-d9b6304e-1 BDBM495491 CVD-0016655
ALP-POS-ddb41b15-9 BDBM496467 CVD-0009917
ALP-POS-e0fe77e5-13 CVD-0015323 BDBM495807
ALP-POS-e6e0c683-3 BDBM495407 CVD-0017229
ALP-POS-e980f4ea-26 BDBM495982 CVD-0014587
ALP-POS-e980f4ea-58 CVD-0014595 BDBM495986
ALP-POS-f13221e1-2 CVD-0012927 BDBM496362
ALP-POS-f13221e1-3 CVD-0012928 BDBM496363
ALP-POS-f13221e1-4 CVD-0012929 BDBM496364
ALP-UNI-3735e77e-4 CVD-0015024 BDBM495882
ALP-UNI-8d415491-1 CVD-0016482 BDBM495560
ALP-UNI-8d415491-3 CVD-0016484 BDBM495562
ALP-UNI-8d415491-4 CVD-0016485 BDBM495563
ALP-UNI-8d415491-5 BDBM495564 CVD-0016486
ALP-UNI-8d415491-6 BDBM495565 CVD-0016487
ALP-UNI-c3ef0aba-1 CVD-0016475 BDBM495571
BDBM495336 ALP-POS-82da25a3-1 CVD-0017474
BDBM495426 CVD-0017025 ALP-UNI-dbb9503d-1
BDBM495427 ALP-UNI-dbb9503d-2 CVD-0017026
BDBM495478 CVD-0016780 ALP-POS-9c80c481-1
BDBM495523 CVD-0016551 ALP-POS-42f3de95-1
BDBM495525 ALP-POS-42f3de95-3 CVD-0016553
BDBM495526 ALP-POS-95f71980-2 CVD-0016511
BDBM495527 ALP-POS-95f71980-3 CVD-0016512
BDBM495528 ALP-POS-95f71980-4 CVD-0016513
BDBM495531 ALP-POS-95f71980-11 CVD-0016520
BDBM495532 ALP-POS-95f71980-14 CVD-0016523
BDBM495533 ALP-POS-95f71980-15 CVD-0016524
BDBM495534 ALP-POS-95f71980-16 CVD-0016525
BDBM495537 ALP-POS-95f71980-21 CVD-0016530
BDBM495538 ALP-POS-95f71980-22 CVD-0016531
BDBM495542 ALP-POS-95f71980-26 CVD-0016535
BDBM495543 ALP-POS-95f71980-27 CVD-0016536
BDBM495544 CVD-0016537 ALP-POS-95f71980-28
BDBM495545 ALP-POS-95f71980-33 CVD-0016542
BDBM495546 ALP-POS-95f71980-34 CVD-0016543
BDBM495547 ALP-POS-95f71980-35 CVD-0016544
BDBM495548 ALP-POS-95f71980-36 CVD-0016545
BDBM495549 ALP-POS-95f71980-37 CVD-0016546
BDBM495604 CVD-0016274 ALP-POS-d0876c20-1
BDBM495607 ALP-POS-d0876c20-4 CVD-0016277
BDBM495610 CVD-0016284 ALP-POS-d0876c20-11
BDBM495611 CVD-0016285 ALP-POS-d0876c20-12
BDBM495612 ALP-POS-d0876c20-14 CVD-0016287
BDBM495641 CVD-0015847 ALP-POS-fe871b40-2
BDBM495642 ALP-POS-fe871b40-11 CVD-0015853
BDBM495644 ALP-UNI-8e43a71e-2 CVD-0015765
BDBM495648 ALP-UNI-8e43a71e-16 CVD-0015775
BDBM495652 CVD-0015717 ALP-POS-88a7a97e-6
BDBM495653 ALP-POS-88a7a97e-8 CVD-0015719
BDBM495654 ALP-POS-88a7a97e-9 CVD-0015720
BDBM495658 CVD-0015727 ALP-POS-88a7a97e-16
BDBM495659 CVD-0015728 ALP-POS-88a7a97e-17
BDBM495665 CVD-0015737 ALP-POS-88a7a97e-26
BDBM495666 CVD-0015738 ALP-POS-88a7a97e-27
BDBM495667 ALP-POS-88a7a97e-29 CVD-0015740
BDBM495674 CVD-0015748 ALP-POS-88a7a97e-37
BDBM495675 CVD-0015749 ALP-POS-88a7a97e-38
BDBM495676 ALP-POS-88a7a97e-39 CVD-0015750
BDBM495677 ALP-POS-88a7a97e-40 CVD-0015751
BDBM495681 ALP-POS-88a7a97e-44 CVD-0015755
BDBM495685 CVD-0015760 ALP-POS-88a7a97e-49
BDBM495730 ALP-POS-ced8ea4d-9 CVD-0015445
BDBM495731 ALP-POS-ced8ea4d-10 CVD-0015446
BDBM495732 ALP-POS-ced8ea4d-11 CVD-0015447
BDBM495735 CVD-0015450 ALP-POS-ced8ea4d-14
BDBM495736 CVD-0015452 ALP-POS-ced8ea4d-16
BDBM495740 ALP-POS-ced8ea4d-20 CVD-0015456
BDBM495741 ALP-POS-ced8ea4d-21 CVD-0015457
BDBM495742 ALP-POS-ced8ea4d-22 CVD-0015458
BDBM495744 CVD-0015460 ALP-POS-ced8ea4d-24
BDBM495745 CVD-0015461 ALP-POS-ced8ea4d-25
BDBM495746 CVD-0015462 ALP-POS-ced8ea4d-26
BDBM495747 CVD-0015463 ALP-POS-ced8ea4d-27
BDBM495751 ALP-POS-ced8ea4d-31 CVD-0015467
BDBM495752 ALP-POS-ced8ea4d-32 CVD-0015468
BDBM495753 ALP-POS-ced8ea4d-33 CVD-0015469
BDBM495754 CVD-0015470 ALP-POS-ced8ea4d-34
BDBM495755 CVD-0015471 ALP-POS-ced8ea4d-35
BDBM495756 CVD-0015472 ALP-POS-ced8ea4d-36
BDBM495757 CVD-0015473 ALP-POS-ced8ea4d-37
BDBM495758 ALP-POS-ced8ea4d-40 CVD-0015476
BDBM495762 CVD-0015484 ALP-POS-ced8ea4d-48
BDBM495763 CVD-0015485 ALP-POS-ced8ea4d-49
BDBM495764 ALP-POS-ced8ea4d-50 CVD-0015486
BDBM495765 CVD-0015491 ALP-POS-ced8ea4d-55
BDBM495768 CVD-0015494 ALP-POS-ced8ea4d-58
BDBM495773 ALP-POS-5bb456a5-3 CVD-0015386
BDBM495775 CVD-0015391 ALP-POS-5bb456a5-8
BDBM495785 ALP-POS-2da19ca7-2 CVD-0015367
BDBM495885 ALP-POS-869ac754-2 CVD-0015013
BDBM495887 ALP-POS-305f6ec3-1 CVD-0014920
BDBM495888 CVD-0014921 ALP-POS-305f6ec3-2
BDBM495889 ALP-POS-305f6ec3-3 CVD-0014922
BDBM495894 ALP-POS-305f6ec3-8 CVD-0014927
BDBM495895 ALP-POS-305f6ec3-9 CVD-0014928
BDBM495897 ALP-POS-305f6ec3-12 CVD-0014931
BDBM495898 ALP-POS-305f6ec3-13 CVD-0014932
BDBM495899 ALP-POS-305f6ec3-14 CVD-0014933
BDBM495900 ALP-POS-305f6ec3-15 CVD-0014934
BDBM495901 ALP-POS-305f6ec3-16 CVD-0014935
BDBM495908 ALP-POS-305f6ec3-24 CVD-0014943
BDBM495910 ALP-POS-305f6ec3-26 CVD-0014945
BDBM495911 ALP-POS-305f6ec3-27 CVD-0014946
BDBM495912 ALP-POS-305f6ec3-28 CVD-0014947
BDBM495919 ALP-POS-305f6ec3-35 CVD-0014954
BDBM495920 ALP-POS-305f6ec3-36 CVD-0014955
BDBM495921 ALP-POS-305f6ec3-37 CVD-0014956
BDBM495923 ALP-POS-305f6ec3-39 CVD-0014958
BDBM495930 ALP-POS-305f6ec3-46 CVD-0014965
BDBM495931 ALP-POS-305f6ec3-49 CVD-0014968
BDBM495937 ALP-POS-305f6ec3-56 CVD-0014975
BDBM495938 ALP-POS-305f6ec3-57 CVD-0014976
BDBM495940 ALP-POS-305f6ec3-59 CVD-0014978
BDBM495984 CVD-0014590 ALP-POS-e980f4ea-32
BDBM495985 CVD-0014593 ALP-POS-e980f4ea-54
BDBM495991 ALP-POS-ce760d3f-1 CVD-0014502
BDBM495993 ALP-POS-ce760d3f-3 CVD-0014504
BDBM495995 ALP-POS-ce760d3f-8 CVD-0014508
BDBM496065 CVD-0014206 ALP-POS-a1bdc92a-1
BDBM496080 CVD-0013917 ALP-POS-79636100-3
BDBM496081 CVD-0013915 ALP-POS-568d9d36-1
BDBM496090 ALP-POS-02c6a514-19 CVD-0013866
BDBM496091 ALP-POS-02c6a514-22 CVD-0013867
BDBM496092 CVD-0013869 ALP-POS-02c6a514-26
BDBM496093 CVD-0013870 ALP-POS-02c6a514-31
BDBM496098 ALP-POS-02c6a514-44 CVD-0013875
BDBM496104 CVD-0013881 ALP-POS-02c6a514-51
BDBM496105 CVD-0013882 ALP-POS-02c6a514-52
BDBM496106 CVD-0013883 ALP-POS-02c6a514-53
BDBM496108 ALP-POS-02c6a514-56 CVD-0013886
BDBM496114 CVD-0013836 ALP-POS-b0bc6a46-7
BDBM496115 ALP-POS-b0bc6a46-8 CVD-0013837
BDBM496116 CVD-0013839 ALP-POS-b0bc6a46-10
BDBM496117 CVD-0013840 ALP-POS-b0bc6a46-11
BDBM496125 CVD-0013849 ALP-POS-b0bc6a46-20
BDBM496127 CVD-0013851 ALP-POS-b0bc6a46-22
BDBM496136 ALP-POS-cd485364-1 CVD-0013825
BDBM496137 ALP-POS-cd485364-2 CVD-0013826
BDBM496324 CVD-0013031 ALP-POS-a3de0cb1-1
BDBM496325 CVD-0013033 ALP-POS-a3de0cb1-3
BDBM496326 CVD-0013035 ALP-POS-a3de0cb1-5
BDBM496345 ALP-POS-6d04362c-5 CVD-0012952
BDBM496466 CVD-0009916 ALP-POS-ddb41b15-8
BDBM496524 CVD-0007225 ALP-POS-d2866bdf-1
BDBM496566 ALP-POS-c0c213c9-10 CVD-0006327
BDBM496567 ALP-POS-c0c213c9-11 CVD-0006328
BDBM496568 CVD-0006330 ALP-POS-c0c213c9-13
BDBM496570 CVD-0006332 ALP-POS-c0c213c9-15
BDBM496571 CVD-0006335 ALP-POS-c0c213c9-18
BDBM496655 ALP-POS-95b75b4d-1 CVD-0004557
BDBM627745 CVD-0017818 ALP-POS-f1807566-1
BDBM627807 ALP-POS-a577c8a2-1 CVD-0017316
BDBM627958 ALP-POS-1cbc2fae-2 CVD-0018249
BDBM628052 ALP-POS-c56c1477-4 CVD-0018428
CVD-0006318 ALP-POS-c0c213c9-1 BDBM496559
CVD-0009757 ALP-POS-3fc1724e-1 BDBM496492
CVD-0009909 ALP-POS-ddb41b15-1 BDBM496463
CVD-0009911 ALP-POS-ddb41b15-3 BDBM496464
CVD-0009912 ALP-POS-ddb41b15-4 BDBM496465
CVD-0012948 ALP-POS-6d04362c-1 BDBM496341
CVD-0012950 ALP-POS-6d04362c-3 BDBM496343
CVD-0013036 BDBM496327 ALP-POS-a3de0cb1-6
CVD-0013037 ALP-POS-a3de0cb1-7 BDBM496328
CVD-0013041 ALP-POS-a3de0cb1-12 BDBM496330
CVD-0013042 ALP-POS-a3de0cb1-13 BDBM496331
CVD-0013043 BDBM496332 ALP-POS-a3de0cb1-14
CVD-0013044 BDBM496333 ALP-POS-a3de0cb1-15
CVD-0013058 ALP-POS-87c86d55-1 BDBM496321
CVD-0013059 ALP-POS-87c86d55-2 BDBM496322
CVD-0013213 BDBM496236 ALP-POS-477dc5b7-3
CVD-0013214 BDBM627867 ALP-POS-477dc5b7-4
CVD-0013828 ALP-POS-e2fddb0f-2 BDBM496135
CVD-0013830 ALP-POS-b0bc6a46-1 BDBM496110
CVD-0013841 ALP-POS-b0bc6a46-12 BDBM496118
CVD-0013848 BDBM496124 ALP-POS-b0bc6a46-19
CVD-0013850 BDBM496126 ALP-POS-b0bc6a46-21
CVD-0013852 BDBM496128 ALP-POS-b0bc6a46-23
CVD-0013859 BDBM496084 ALP-POS-02c6a514-6
CVD-0013861 ALP-POS-02c6a514-10 BDBM496086
CVD-0013862 BDBM496087 ALP-POS-02c6a514-11
CVD-0013871 ALP-POS-02c6a514-32 BDBM496094
CVD-0013872 BDBM496095 ALP-POS-02c6a514-33
CVD-0013873 ALP-POS-02c6a514-34 BDBM496096
CVD-0013874 ALP-POS-02c6a514-40 BDBM496097
CVD-0013879 BDBM496102 ALP-POS-02c6a514-49
CVD-0013885 BDBM496107 ALP-POS-02c6a514-55
CVD-0013893 BDBM496082 ALP-POS-902f21bb-1
CVD-0013938 ALP-POS-6495d03e-6 BDBM496077
CVD-0013939 ALP-POS-6495d03e-7 BDBM496078
CVD-0014179 ALP-UNI-4b8a177c-1 BDBM496067
CVD-0014383 ALP-POS-696356e4-1 BDBM496003
CVD-0014589 BDBM495983 ALP-POS-e980f4ea-31
CVD-0014596 BDBM495987 ALP-POS-e980f4ea-61
CVD-0014925 ALP-POS-305f6ec3-6 BDBM495892
CVD-0015437 BDBM495723 ALP-POS-ced8ea4d-1
CVD-0015438 ALP-POS-ced8ea4d-2 BDBM495724
CVD-0015448 BDBM495733 ALP-POS-ced8ea4d-12
CVD-0015449 BDBM495734 ALP-POS-ced8ea4d-13
CVD-0015459 BDBM495743 ALP-POS-ced8ea4d-23
CVD-0015481 ALP-POS-ced8ea4d-45 BDBM495760
CVD-0015483 ALP-POS-ced8ea4d-47 BDBM495761
CVD-0015492 BDBM495766 ALP-POS-ced8ea4d-56
CVD-0015493 BDBM495767 ALP-POS-ced8ea4d-57
CVD-0015503 ALP-POS-ced8ea4d-67 BDBM495771
CVD-0015714 BDBM495649 ALP-POS-88a7a97e-3
CVD-0015715 ALP-POS-88a7a97e-4 BDBM495650
CVD-0015716 ALP-POS-88a7a97e-5 BDBM495651
CVD-0015724 BDBM495656 ALP-POS-88a7a97e-13
CVD-0015726 BDBM495657 ALP-POS-88a7a97e-15
CVD-0015734 BDBM495662 ALP-POS-88a7a97e-23
CVD-0015735 BDBM495663 ALP-POS-88a7a97e-24
CVD-0015736 BDBM495664 ALP-POS-88a7a97e-25
CVD-0015745 BDBM495672 ALP-POS-88a7a97e-34
CVD-0015747 ALP-POS-88a7a97e-36 BDBM495673
CVD-0015757 ALP-POS-88a7a97e-46 BDBM495682
CVD-0015758 ALP-POS-88a7a97e-47 BDBM495683
CVD-0015759 ALP-POS-88a7a97e-48 BDBM495684
CVD-0015767 BDBM495645 ALP-UNI-8e43a71e-7
CVD-0015768 BDBM495646 ALP-UNI-8e43a71e-8
CVD-0015769 BDBM495647 ALP-UNI-8e43a71e-10
CVD-0016275 BDBM495605 ALP-POS-d0876c20-2
CVD-0016276 ALP-POS-d0876c20-3 BDBM495606
CVD-0016280 ALP-POS-d0876c20-7 BDBM495609
CVD-0016290 ALP-POS-d0876c20-17 BDBM495614
CVD-0016294 BDBM495616 ALP-POS-d0876c20-21
CVD-0016295 ALP-POS-d0876c20-22 BDBM495617
CVD-0016476 ALP-UNI-c3ef0aba-3 BDBM495572
CVD-0016483 ALP-UNI-8d415491-2 BDBM495561
CVD-0016490 BDBM495559 ALP-POS-a0a4abd7-1
CVD-0016515 BDBM495529 ALP-POS-95f71980-6
CVD-0016519 ALP-POS-95f71980-10 BDBM495530
CVD-0016527 BDBM495535 ALP-POS-95f71980-18
CVD-0016528 BDBM495536 ALP-POS-95f71980-19
CVD-0017391 ALP-POS-a2344586-1 BDBM495353
CVD-0018052 BDBM628061 ALP-POS-6479a3a9-1
BDBM496556 ALP-POS-c59291d4-4 CVD-0006353 acs.jmedchem.1c00409_ST.297
BDBM496109 ALP-POS-02c6a514-57 US20240083885, Compound Jun8-50-2 CVD-0013887
BDBM429461 ALP-POS-c59291d4-2 CVD-0006351 acs.jmedchem.1c00409_ST.325 med.21724, Compound 133
US20240083885, Compound Jun8-48-1 ALP-POS-c59291d4-6 BDBM429328 jm5b01461, Compound 146 CVD-0006355
ALP-POS-c59291d4-3 ML300-based SC inhibitor 1 CVD-0006352 BDBM479369 US20240239772, Compound ML300 acs.jmedchem.1c00409_ST.352
ALP-POS-c59291d4-1 acs.jmedchem.1c00409_ST.38 BDBM429465 CVD-0006350 ML300-based SC inhibitor 7 med.21724, Compound 137
- Mahboobi, S; Uecker, A; Cénac, C; Sellmer, A; Eichhorn, E; Elz, S; Böhmer, FD; Dove, S Bioorg Med Chem 15: 2187-97 (2007)
- Alp, C; Ekinci, D; Gültekin, MS; Sentürk, M; Sahin, E; Küfrevioglu, OI Bioorg Med Chem 18: 4468-74 (2010)
- Chua, GNL; Wassarman, KL; Sun, H; Alp, JA; Jarczyk, EI; Kuzio, NJ; Bennett, MJ; Malachowsky, BG; Kruse, M; Kennedy, AJ ACS Med Chem Lett 10: 180-185 (2019)
- Alp, C; Maresca, A; Alp, NA; Gültekin, MS; Ekinci, D; Scozzafava, A; Supuran, CT J Enzyme Inhib Med Chem 28: 294-8 (2013)
- ChEMBL_1781839 (CHEMBL4253356) Inhibition of Streptococcus agalactiae WB1445 FabK in presence of t-O-NAC and NADH up to 1 min by spectrophotometric analysis
- ChEMBL_2469666 Inhibition of recombinant human HDAC1 using Ac-Val-Gly-(NAc)Lys-AMC as substrate incubated for 30 mins by fluorescence based assay
- ChEMBL_2469667 Inhibition of recombinant human HDAC6 using Ac-Val-Gly-(NAc)Lys-AMC as substrate incubated for 30 mins by fluorescence based assay
- ChEMBL_1462739 (CHEMBL3399508) Inhibition of Staphylococcus aureus FabI-mediated trans-2-octenoyl N-acetylcysteamine (t-o-NAC thioester) substrate reduction assessed as decrease in NADPH by ELISA
- ChEMBL_332772 (CHEMBL859110) Effect on transactivation of ALP gene expression in HEK293 cells transfected with hERalpha
- ChEMBL_332773 (CHEMBL859111) Effect on transactivation of ALP gene expression in HEK293 cells transfected with hERbeta
- ChEMBL_1988429 (CHEMBL4621976) Inhibition of human eNOS using L-argininge as substrate preincubated for 15 mins followed by NADPH addition and measured after 20 mins by OPA/NAC reagent based HPLC analysis
- ChEMBL_1988428 (CHEMBL4621975) Inhibition of recombinant human nNOS expressed in Escherichia coli using L-arginine as substrate preincubated for 15 mins followed by NADPH addition and measured after 20 mins by OPA/NAC reagent based HPLC-fluorimetric analysis
- ChEMBL_1988427 (CHEMBL4621974) Inhibition of recombinant N-terminal His-tagged human iNOS expressed in Escherichia coli using L-arginine as substrate preincubated for 15 mins followed by NADPH addition and measured after 20 mins by OPA/NAC reagent based HPLC-fluorimetric analysis
- Inhibition Assay The assay buffer AB contained 50 mM ADA (N-(2-acetamido)iminodiacetic acid monosodium salt) pH 6.5, 1 mM dithiothreitol, 0.006% Triton-X100 and 50 mM NaCl. The following components are added in a white polystyrene Costar plate (Ref 3912) up to a final volume of 55.5 uL: 1.5 uL DMSO or inhibitor dissolved in DMSO and 54 uL of a FabI/NADPH/NADP+ mixture in AB. After 60 min of pre-incubation at room temperature, the reaction is started by addition of 5 uL of trans-2-octenoyl N-acetylcysteamine thioester (t-o-NAC) to a final volume of 60.5 uL. This reaction mixture is then composed of 2 nM FabI, 40 uM NADPH (Sigma, N7505), 10 uM NADP+ (Sigma, N5755), 100 uM t-O-NAC and compound at defined concentration. Fluorescence intensity of NADPH (lamda=ex=360 nm, lamda=em=520 nm) is measured immediately after t-O-NAC addition (T0), and approximately 50 min later (T50) by a Fluostar Optima (BMG).
- Fluorescence Based Assay The assay buffer "AB" contained 50 mM ADA (N-(2-acetamido)iminodiacetic acid monosodium salt) pH 6.5, 1 mM dithiothreitol, 0.006% Triton-X100 and 50 mM NaCl. The following components are added in a white polystyrene Costar plate (Ref 3912) up to a final volume of 55.5 uL: 1.5 uL DMSO or inhibitor dissolved in DMSO and 54 uL of a FabI/NADPH/NADP+ mixture in AB. After 60 min of pre-incubation at room temperature, the reaction is started by addition of 5 uL of trans-2-octenoyl N-acetylcysteamine thioester (t-o-NAC) to a final volume of 60.5 uL. This reaction mixture is then composed of 2 nM FabI, 40 uM NADPH (Sigma, N7505), 10 uM NADP+(Sigma, N5755), 100 uM t-O-NAC and compound at defined concentration. Fluorescence intensity of NADPH (lamda=ex=360 nm, lamda=em=520 nm) is measured immediately after t-O-NAC addition (T0), and approximately 50 min later (T50) by a Fluostar Optima (BMG) so as to achieve ~30% of NADPH conversion.
- GR Binding Assay and GRAF Assay For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(H)-dex) was determined by a nonlinear four parameter logistic model. The EC50s are the concentrations of compounds required to inhibit 50% of dexamethasone-induced alkaline phosphatase (ALP) expression in GRAF cell line, which is produced by CHO-K1 cells stably transfected with GR and a reporter construct containing a glucocorticoid response element driving expression of ALP.
- Fluorescence Based Assay Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S. aureus is prepared and purified using standard methods for recombinant protein expression after cloning of the gene in a prokaryotic expression vector.The biochemical activity of the FabI enzyme is assessed using the following method.The assay buffer AB contained 50 mM ADA (N-(2-acetamido)iminodiacetic acid monosodium salt) pH 6.5, 1 mM dithiothreitol, 0.006% Triton-X100 and 50 mM NaCl.The following components are added in a white polystyrene Costar plate (Ref 3912) up to a final volume of 55.5 uL: 1.5 uL DMSO or inhibitor dissolved in DMSO and 54 uL of a FabI/NADPH/NADP+ mixture in AB. After 60 min of pre-incubation at room temperature, the reaction is started by addition of 5 uL of trans-2-octenoyl N-acetylcysteamine thioester (t-o-NAC) to a final volume of 60.5 uL.
- Electrophysiological Assay (In Vitro Assay) Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and allows the determination of the time- and voltage-dependence of block which has been interpreted as differential binding to the resting, open, and inactivated states of the sodium channel (Hille, B., Journal of General Physiology (1977), 69: 497-515).The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney cells (HEK), permanently transfected with an expression vector containing the full-length cDNA coding for the desired human sodium channel α-subunit, grown in culture media containing 10% FBS, 1% PSG, and 0.5 mg/mL G418 at 37° C. with 5% CO2. HEK cells used for the electrophysiology (EP) recordings had a passage number of less than 40 for all studies and were used within three days from the time of plating. NaV1.1, NaV1.5 and NaV1.6 cDNAs (NM_001165964 (SCN1A), NM_000335 (SCN5A) and NM_014191 (SCN8A), respectively) were stably expressed in HEK-293 cells.Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or manually using an Axopatch 200B (Axon Instruments) or Model 2400 (A-M systems) amplifier. The manual voltage clamp protocol was as follows: Borosilicate glass micropipettes were fire-polished to a tip diameter yielding a resistance of 2-4 Mohms in the working solutions. The pipette was filled with a solution comprised of: 5 mM NaCl, 10 mM CsCl, 120 mM CsF, 0.1 mM CaCl2, 2 mM MgCl2, 10 mM HEPES, 10 mM EGTA; and adjusted to pH 7.2 with CsOH. The external solution had the following composition: 140 mM NaCl, 5 mM KCl, 2 mM CaCl2, 1 mM MgCl2, 10 mM HEPES; and adjusted to pH 7.4 with NaOH. In some studies, the external sodium was reduced by equimolar replacement with choline. Osmolarity in the CsF internal and NaC external solutions was adjusted to 300 mOsm/kg and 310 mOsm/kg with glucose, respectively. All recordings were performed at ambient temperature in a bath chamber with a volume of 150 μL. Control sodium currents were measured in 0.5% DMSO. Controls and representative compounds of the invention were applied to the recording chamber through a 4-pinch or 8-pinch valve bath perfusion system manufactured by ALA Scientific Instruments.Currents were recorded at 40 kHz sampling frequency, filtered at 5 Hz, and stored using a Digidata-1322A analogue/digital interface with the pClamp software (Axon Instruments). Series resistance compensation was applied (60-80%). Cells were rejected if currents showed inadequate voltage control (as judged by the IV relationship during stepwise activation). All statistics in this study are given as mean±SD.The membrane potential was maintained at a voltage where inactivation of the channel is complete. The voltage is then stepped back to a very negative (Vhold=−150 mV) voltage for 20 ms and then a test pulse is applied to quantify the compound block. The 20 ms brief repolarization was long enough for compound-free channels to completely recover from fast inactivation, but the compound-bound channels recovered more slowly such that negligible recovery could occur during this interval. The percent decrease in sodium current following wash-on of compound was taken as the percent block of sodium channels.