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Query String: Rosa davurica Pall.

Thao, NP; Luyen, BT; Tai, BH; Yang, SY; Jo, SH; Cuong, NX; Nam, NH; Kwon, YI; Minh, CV; Kim, YH Rat intestinal sucrase inhibition of constituents from the roots of Rosa rugosa Thunb. Bioorg Med Chem Lett 24: 1192-6 (2014)

Adams, GL; Pall, PS; Grauer, SM; Zhou, X; Ballard, JE; Vavrek, M; Kraus, RL; Morissette, P; Li, N; Colarusso, S; Bianchi, E; Palani, A; Klein, R; John, CT; Wang, D; Tudor, M; Nolting, AF; Biba, M; Nowak, T; Makarov, AA; Reibarkh, M; Buevich, AV; Zhong, W; Regalado, EL; Wang, X; Gao, Q; Shahripour, A; Zhu, Y; de Simone, D; Frattarelli, T; Pasquini, NM; Magotti, P; Iaccarino, R; Li, Y; Solly, K; Lee, KJ; Wang, W; Chen, F; Zeng, H; Wang, J; Regan, H; Amin, RP; Regan, CP; Burgey, CS; Henze, DA; Sun, C; Tellers, DM J Med Chem 65: 485-496 (2022)
Camps, P; Formosa, X; Galdeano, C; Gómez, T; Muñoz-Torrero, D; Scarpellini, M; Viayna, E; Badia, A; Clos, MV; Camins, A; Pallàs, M; Bartolini, M; Mancini, F; Andrisano, V; Estelrich, J; Lizondo, M; Bidon-Chanal, A; Luque, FJ J Med Chem 51: 3588-98 (2008)
CODONY I GISBERT, S; GRIÑAN FERRE, CG; PALLÀS LLIBERIA, M; VÁZQUEZ CRUZ, S; OH, Y US Patent US20240182406 (2024)
GUNNING, PT; OMEARA, J; AHMAR, S; SIMPSON, GL; HUNT, P; ROSA, DA; PARK, JS US Patent US20240018153 (2024)
Caleffi, GS; Rosa, AS; de Souza, LG; Avelar, JLS; Nascimento, SMR; de Almeida, VM; Tucci, AR; Ferreira, VN; da Silva, AJM; Santos-Filho, OA; Miranda, MD; Costa, PRR J Nat Prod 86: 1536-1549 (2023)
Fontenla, JA; Osuna, J; Rosa, E; Castro, ME; G-Ferreiro, T; Loza-García, I; Calleja, JM; Sanz, F; Rodríguez, J; Raviña, E J Med Chem 37: 2564-73 (1994)
Gonçalves, DS; de S Melo, SM; Jacomini, AP; J V da Silva, M; Pianoski, KE; Ames, FQ; Aguiar, RP; Oliveira, AF; Volpato, H; Bidóia, DL; Nakamura, CV; Bersani-Amado, CA; Back, DF; Moura, S; Paula, FR; Rosa, FA Bioorg Med Chem 28: (2020)
Rosa, GP; Palmeira, A; Resende, DISP; Almeida, IF; Kane-Pagès, A; Barreto, MC; Sousa, E; Pinto, MMM Bioorg Med Chem 29: (2021)
Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH Bioorg Med Chem Lett 7: 7-10 (1997)
Rosa, JG; Lee, J; Marrero, D; Adamus, JE; Villa-Mora, S US Patent US10155733 (2018)
Rosa, M; Gonzalez-Nunez, V; Barreto-Valer, K; Marcelo, F; Sánchez-Sánchez, J; Calle, LP; Arévalo, JC; Rodríguez, RE; Jiménez-Barbero, J; Arsequell, G; Valencia, G Bioorg Med Chem 25: 2260-2265 (2017)
Schmitt, J; Goodfellow, E; Huang, S; Williams, C; Gomes, INF; Rosa, MN; Reis, RM; Yang, R; Titi, HM; Jean-Claude, BJ Eur J Med Chem 192: (2020)
Smith, CJ; Ali, A; Hammond, ML; Li, H; Lu, Z; Napolitano, J; Taylor, GE; Thompson, CF; Anderson, MS; Chen, Y; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Sparrow, CP; Wright, SD; Cumiskey, AM; Latham, M; Peterson, LB; Rosa, R; Pivnichny, JV; Tong, X; Xu, SS; Sinclair, PJ J Med Chem 54: 4880-95 (2011)
Szewczyk, JW; Huang, S; Chin, J; Tian, J; Mitnaul, L; Rosa, RL; Peterson, L; Sparrow, CP; Adams, AD Bioorg Med Chem Lett 16: 3055-60 (2006)
McConville, M; Fernández, J; Angulo-Barturen, Í; Bahamontes-Rosa, N; Ballell-Pages, L; Castañeda, P; de Cózar, C; Crespo, B; Guijarro, L; Jiménez-Díaz, MB; Martínez-Martínez, MS; de Mercado, J; Santos-Villarejo, Á; Sanz, LM; Frigerio, M; Washbourn, G; Ward, SA; Nixon, GL; Biagini, GA; Berry, NG; Blackman, MJ; Calderón, F; O'Neill, PM J Med Chem 58: 6448-55 (2015)
Campos Rosa, J; Galanakis, D; Piergentili, A; Bhandari, K; Ganellin, CR; Dunn, PM; Jenkinson, DH J Med Chem 43: 420-31 (2000)
Gomez-Monterrey, I; Sala, M; Rusciano, MR; Monaco, S; Maione, AS; Iaccarino, G; Tortorella, P; D'Ursi, AM; Scrima, M; Carotenuto, A; De Rosa, G; Bertamino, A; Vernieri, E; Grieco, P; Novellino, E; Illario, M; Campiglia, P Eur J Med Chem 62: 425-34 (2013)
De Rosa, M; Giordano, S; Scettri, A; Sodano, G; Soriente, A; Pastor, PG; Alcaraz, MJ; Payá, M J Med Chem 41: 3232-8 (1998)
De Rosa, S; Crispino, A; De Giulio, A; Iodice, C; Benrezzouk, R; Terencio, MC; Ferrándiz, ML; Alcaraz, MJ; Payá, M J Nat Prod 61: 931-5 (1998)
Pesci, E; Bettinetti, L; Fanti, P; Galietta, LJ; La Rosa, S; Magnoni, L; Pedemonte, N; Sardone, GL; Maccari, L J Med Chem 58: 9697-711 (2015)
Bernard-Gauthier, V; Boudjemeline, M; Rosa-Neto, P; Thiel, A; Schirrmacher, R Bioorg Med Chem 21: 7816-29 (2013)
da Rosa, R; de Moraes, MH; Zimmermann, LA; Schenkel, EP; Steindel, M; Bernardes, LSC Eur J Med Chem 128: 25-35 (2017)
Peduto, A; Scuotto, M; Krauth, V; Roviezzo, F; Rossi, A; Temml, V; Esposito, V; Stuppner, H; Schuster, D; D'Agostino, B; Schiraldi, C; de Rosa, M; Werz, O; Filosa, R Eur J Med Chem 127: 715-726 (2017)
Kazmierski, WM; Xia, B; Miller, J; De la Rosa, M; Favre, D; Dunham, RM; Washio, Y; Zhu, Z; Wang, F; Mebrahtu, M; Deng, H; Basilla, J; Wang, L; Evindar, G; Fan, L; Olszewski, A; Prabhu, N; Davie, C; Messer, JA; Samano, V J Med Chem 63: 3552-3562 (2020)
Lopes da Rosa, J; Bajaj, V; Spoonamore, J; Kaufman, PD Bioorg Med Chem Lett 23: 2853-9 (2013)
Liotta, DC; Painter, GR; Bluemling, GR; de la Rosa, A US Patent US11857560 (2024)
Calderón, F; Vidal-Mas, J; Burrows, J; de la Rosa, JC; Jiménez-Díaz, MB; Mulet, T; Prats, S; Solana, J; Witty, M; Gamo, FJ; Fernández, E ACS Med Chem Lett 3: 373-377 (2012)
Macedo Vaz, S; de Freitas Silva, M; Dos Reis Rosa Franco, G; Jorge R Guimarães, M; Motta R da Silva, F; Gonçalves Castro, N; Alvim Guedes, I; Dardenne, LE; Amaral Alves, M; Garrett da Costa, R; Beserra Pinheiro, G; Germino Veras, L; Renata Mortari, M; Pruccoli, L; Tarozzi, A; Viegas, C Bioorg Med Chem 71: (2022)
Ramírez-Espinosa, JJ; Rios, MY; Paoli, P; Flores-Morales, V; Camici, G; de la Rosa-Lugo, V; Hidalgo-Figueroa, S; Navarrete-Vázquez, G; Estrada-Soto, S Eur J Med Chem 87: 316-27 (2014)
Martín-Martínez, M; Pérez-Gordillo, FL; Álvarez de la Rosa, D; Rodríguez, Y; Gerona-Navarro, G; González-Muñiz, R; Zhou, MM J Med Chem 60: 2629-2650 (2017)

Competitive Binding Assay Using Eu-NDP-a-MSH A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination by time-resolved fluorometry (TRF) of the lanthanide chelate. In comparison studies with [I125]-NDP-α-MSH, the same values, within experimental error ranges, were obtained for percent inhibition and Ki. Typically competition experiments to determine Ki values were conducted by incubating membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R with 9 different concentrations of test compounds of interest and 2 nM of Eu-NDP-α-MSH in a solution containing 25 mM HEPES buffer with 100 mM NaCl, 2 mM CaCl2, 2 mM MgCl2 and 0.3 mM 1,10-phenanthroline. After incubation for 90 minutes at 37° C., the reaction was stopped by filtration over AcroWell 96-well filter plates (Pall Life Sciences). The filter plates were washed 4 times with 200 uL of ice-cold phosphate-buffered saline. DELFIA Enhancement solution (PerkinElmer Life Sciences) was added to each well. The plates were incubated on a shaker for 15 minutes and read at 340 nm excitation and 615 nm emission wavelengths. Each assay was conducted in duplicate and mean values were utilized. Ki values were determined by curve-fitting with Graph-Pad Prism software using a one-site fixed-slope competition binding model.