TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 143nMAssay Description:Activation of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin)-dependent cleavage of FAM-labeled stem-loop RNA containing the XBP1...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 4.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 5.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 5.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 5.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 7.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 7.00E+3nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: <1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: <100nM EC50: >1.00E+4nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair