Report error Found 30 of ic50 for monomerid = 50507816
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Allosteric inhibition of fluorescein labeled probe binding to His-tagged recombinant human TYK2 pseudokinase JH2 domain (575-869 residues) incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of fluorescein labeled probe binding to human recombinant JAK1 JH2 incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of TYK2 in human PBMC assessed as decrease in IFNalpha-induced STAT5 phosphorylation in CD3+ T cells preincubated for 1 hr followed by sti...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of TYK2 in human Jurkat cells assessed as reduction in IFNalpha induced STAT3 phosphorylation incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of TYK2 dependent IFNalpha-stimulated STAT3 phosphorylation in human Jurkat cellsMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of TYK2 in IFN-alpha stimulated human Kit225 T cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of TYK2 in human PBMC assessed as decrease in IL23-induced STAT3 phosphorylation in CD161+/CD3+ T cells preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Affinity DataIC50: 193nMAssay Description:Inhibition of BMPR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 592nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as decrease in IL2-induced STAT5 phosphorylation in CD3+ T cells preincubated for 1 hr followed by sti...More data for this Ligand-Target Pair
Affinity DataIC50: 609nMAssay Description:Inhibition of JAK1/JAK2 in in human whole blood assessed as decrease in IL6-induced STAT3 phosphorylation in CD3+ T cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 615nMAssay Description:Inhibition of JAK1 in human PBMC assessed as decrease in IL6-induced STAT5 phosphorylation in CD3+ T cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of JAK1/JAK3 in in human whole blood assessed as decrease in IL2-induced STAT5 phosphorylation in CD3+ T cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of JAK1 in human PBMC assessed as decrease in IL13-induced STAT6 phosphorylation in mononuclear cellsMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of fluorescein labeled probe binding to human recombinant TYK2 JH1 domain incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 in human whole blood assessed as decrease in TPO-induced STAT5 phosphorylation in plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of fluorescein labeled probe binding to human recombinant JAK2 JH1 domain incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as decrease in EPO-induced STAT5A phosphorylation incubated for 10 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of fluorescein labeled probe binding to human recombinant JAK3 JH1 domain incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of fluorescein labeled probe binding to human recombinant JAK1 JH1 domain incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human ERG by in vitro patch clamp methodMore data for this Ligand-Target Pair